FMOC-D-LYS-OH HCL

Base Information

• Chemical Name: FMOC-D-LYS-OH HCL
• CAS No.: 201002-47-3
• Molecular Formula: C₂₁H₂₄N₂O₄*ClH
• Molecular Weight: 404.894
• Hs Code.: 2924299090
• Mol file: 201002-47-3.mol

Synonyms:N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-lysine hydrochloride (1:1);

Chemical Property of FMOC-D-LYS-OH HCL

Chemical Property:

• Refractive Index: 11 ° (C=1, DMF)
• PSA: 101.65000
• LogP: 5.00050
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Nα-Fmoc-?D-?lysineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Nα-Fmoc-D-lysine is an N-Fmoc-protected form of D-Lysine (L468930). D-Lysine is the unnatural isomer of L-Lysine (L468895) that has the ability to reduce non-enzymatic glycation in vitro. D-Lysine also exists as polypeptide chains of poly-D-lysine, a nonspecific adhesion-promoting molecule that has the potential to be a polymeric drug carrier.

Technology Process of FMOC-D-LYS-OH HCL

There total 1 articles about FMOC-D-LYS-OH HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-D-Lys(BOC)-OH (92122-45-7) → Fmoc-Lys-OH hydrochloride (201002-47-3,139262-23-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; dichloromethane; for 16h;

DOI:10.1039/c7cc08028j

Reference yield: 100.0%

Fmoc-Lys-OH hydrochloride (201002-47-3,139262-23-0) → (R)-2-{[((9H-fluoren-9-yl)methoxy)carbonyl]amino}-6-azidohexanoic acid

Guidance literature:

With sodium hydrogencarbonate; copper(II) sulfate; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tetlet.2008.07.037

Reference yield:

Fmoc-Lys-OH hydrochloride (201002-47-3,139262-23-0) → C66H92N7O13(1+)*Cl(1-)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide / 0.03 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: piperidine / N,N-dimethyl-formamide / 0.5 h

3.1: N-ethyl-N,N-diisopropylamine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V) / N,N-dimethyl-formamide; dichloromethane / 0.03 h

3.2: 0.08 h

With piperidine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201305510

upstream raw materials:

Fmoc-D-Lys(BOC)-OH

Refernces