Z-GLN-OBZL

Base Information

• Chemical Name: Z-GLN-OBZL
• CAS No.: 95700-16-6
• Molecular Formula: C20H22 N2 O5
• Molecular Weight: 370.405
• Hs Code.: 2924299090
• Mol file: 95700-16-6.mol

Synonyms:Glutamine,N2-carboxy-, dibenzyl ester, L- (6CI,7CI)

Chemical Property of Z-GLN-OBZL

Chemical Property:

• PSA: 107.72000
• LogP: 3.38150

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-GLN-OBZL

There total 8 articles about Z-GLN-OBZL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

→ benzyl 5-amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanoate (95700-16-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

Cbz-(L)-Glu-OBn (3705-42-8) → benzyl 5-amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanoate (95700-16-6)

Guidance literature:

With tetrahydrofuran; tributyl-amine; chloroformic acid ethyl ester; anschliessend Behandeln mit <¹⁵N>Ammoniumnitrat enthaltendem NH4NO3 und Triaethylamin in THF;

Reference yield:

N-(benzyloxycarbonyl)-L-glutamic acid anhydride (4124-76-9) → benzyl 5-amino-2-(((benzyloxy)carbonyl)amino)-5-oxopentanoate (95700-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: benzyl alcohol / 100 °C

2: N-benzyloxycarbonyl-L-glutamic acid-5-benzyl ester; diethyl ether; PCl₅ / unter starker Kuehlung und Behandlung des Reaktionsprodukts mit aether. NH₃ unter Kuehlung

With diethyl ether; N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid; phosphorus pentachloride; benzyl alcohol;

upstream raw materials:

Cbz-(L)-Glu-OBn

benzaldehyde, hydrazone

Cbz-L-Gln

Carbobenzoxy-L-glutaminsaeure-α-benzylester-γ-thiophenylester

Downstream raw materials:

-benzylester

(2S)-4-Amino-2-(benzyloxycarbonylamino)butansaeure-benzylester

(S)-2-benzyloxycarbonylamino-4-[(1S,2R)-2-(2,5-dimethoxyphenyl)-2-hydroxy-1-methyl-ethylcarbamoyl]butyric acid benzyl ester

Z-Gln(Pmbf)-OBzl

Refernces