2-Cyclopropylmethylamino-5-chlorobenzophenone

Base Information

• Chemical Name: 2-Cyclopropylmethylamino-5-chlorobenzophenone
• CAS No.: 2897-00-9
• Molecular Formula: C17H16ClNO
• Molecular Weight: 285.773
• Hs Code.: 2922399090
• Mol file: 2897-00-9.mol

Synonyms:Benzophenone,5-chloro-2-[(cyclopropylmethyl)amino]- (7CI,8CI);2-[(Cyclopropylmethyl)amino]-5-chlorobenzophenone;5-Chloro-2-[(cyclopropylmethyl)amino]benzophenone;

Chemical Property of 2-Cyclopropylmethylamino-5-chlorobenzophenone

Chemical Property:

• Vapor Pressure: 5.42E-09mmHg at 25°C
• Melting Point: 79-80 °C
• Refractive Index: 1.641
• Boiling Point: 469.6 °C at 760 mmHg
• Flash Point: 237.8 °C
• PSA: 29.10000
• Density: 1.252 g/cm³
• LogP: 4.46590

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Cyclopropylmethylamino-5-chlorobenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Cyclopropylmethylamino-5-chlorobenzophenone is a benzodiazepine derivative.

Technology Process of 2-Cyclopropylmethylamino-5-chlorobenzophenone

There total 6 articles about 2-Cyclopropylmethylamino-5-chlorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

5-chloro-2-cyclopropylmethylaminobenzophenone imine (40507-46-8) + trifluoroacetyl chloride (76-02-8) → 6-chloro-1-cyclopropylmethyl-3,4-dihydro-4-phenyl-4-trichloromethyl-2(1H)-quinazolinone (80170-87-2) + 1-Cyclopropylmethyl-4-phenyl-6-chloro-2(1H)-quinazolinone (33453-19-9) + 2-N-cyclopropmethylamino-5-chloro-benzophenone (2897-00-9)

Guidance literature:

With triethylamine; In benzene; for 2h; Ambient temperature;

DOI:10.1248/cpb.29.2135

Reference yield: 13.0%

carbon monoxide (201230-82-2) → 2-Chloro-5-cyclopropylmethyl-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-22-2) + 2-Chloro-5-cyclopropylmethyl-13b-methoxy-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-21-1) + 2-N-cyclopropmethylamino-5-chloro-benzophenone (2897-00-9) + prazepam (2955-38-6)

Guidance literature:

In methanol; chloroform; at 45 - 50 ℃; for 31h; under 76000.1 Torr;

DOI:10.1016/0022-328X(91)86234-H

Reference yield: 13.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) → 2-Chloro-5-cyclopropylmethyl-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-22-2) + 2-Chloro-5-cyclopropylmethyl-13b-methoxy-5,13b-dihydro-benzo[5,6][1,4]diazepino[7,1-a]isoindole-6,9-dione (133489-21-1) + 2-N-cyclopropmethylamino-5-chloro-benzophenone (2897-00-9) + prazepam (2955-38-6)

Guidance literature:

In chloroform; at 45 - 50 ℃; for 31h; under 76000.1 Torr; Title compound not separated from byproducts;

DOI:10.1016/0022-328X(91)86234-H

upstream raw materials:

3-Hydroxyprazepam

5-chloro-2-cyclopropylmethylaminobenzophenone imine

trifluoroacetyl chloride

prazepam

Refernces

• 1、 Cinellu, Maria Agostina,Gladiali, Serafino,Minghetti, Giovanni,Stoccoro, Sergio,Demartin, Francesco. "Cyclometallated derivatives of palladium(II) with 1,4-benzodiazepin-2-ones. Crystal structure of (L-H)Pd(PPh3)ClCHCl3 (L = Prazepam: 7-chloro-1-cyclopropylmethyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one). Synthesis of isoindolobenzodiazepine derivatives by ...". . p. 371 - 384. Retrieved 2007/10/02.
• 2、 Yamamoto,Yamamoto. "Synthetic studies on quinazoline derivatives. II. The reactions of 2-trichloro- and 2-trifluoroacetamidobenzophenones with primary amines". . p. 2135 - 2156. Retrieved 2007/10/02.