(R)-BETA-METHYL-GAMMA-BUTYROLACTONE

Base Information

• Chemical Name: (R)-BETA-METHYL-GAMMA-BUTYROLACTONE
• CAS No.: 65284-00-6
• Molecular Formula: C5H8O2
• Molecular Weight: 100.117
• Mol file: 65284-00-6.mol

Synonyms:2(3H)-Furanone,dihydro-4-methyl-, (R)-;(R)-beta-Methyl-g-butyrolactone;

Chemical Property of (R)-BETA-METHYL-GAMMA-BUTYROLACTONE

Chemical Property:

• Boiling Point: 206.624 °C at 760 mmHg
• Flash Point: 74.98 °C
• PSA: 26.30000
• Density: 1.04 g/cm³
• LogP: 0.56940

Purity/Quality:

98%Min ^*data from raw suppliers

(4R)-4-methyloxolan-2-one 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-BETA-METHYL-GAMMA-BUTYROLACTONE

There total 121 articles about (R)-BETA-METHYL-GAMMA-BUTYROLACTONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methyl-2(5H)-furanone (6124-79-4) → dihydro-4-methyl-2(3H)-furanone (64190-48-3,65284-00-6,70470-05-2,1679-49-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 1500.15 Torr;

DOI:10.1002/chem.201104073

Reference yield: 93.0%

2-Butoxy-4-methyl-tetrahydrofuran (82918-74-9) → dihydro-4-methyl-2(3H)-furanone (64190-48-3,65284-00-6,70470-05-2,1679-49-8)

Guidance literature:

With Jones-reagent; In acetone; at 0 ℃; for 0.25h;

DOI:10.1016/S0040-4020(01)81285-0

Reference yield: 87.0%

Dimethyl itakonate (617-52-7) → 3-methyltetrahydrofuran (13423-15-9) + dihydro-4-methyl-2(3H)-furanone (64190-48-3,65284-00-6,70470-05-2,1679-49-8) + 3-methyltetrahydro-2-furanone (1679-47-6)

Guidance literature:

With C₅₇H₆₉P₃Ru; hydrogen; bis(trifluoromethanesulfonyl)amide; at 200 ℃; for 0.0833333h; under 75007.5 Torr; Autoclave;

upstream raw materials:

4,5-dimethylfuran-2-(3H)-one

3-methyltetrahydrofuran

2-Butoxy-4-methyl-tetrahydrofuran

3-methylbutyric acid

Downstream raw materials:

(R)-3-(3,5-Dimethyl-benzoyl)-4-methyl-dihydro-furan-2-one

(2R-trans)-4-Methyl-2-piperidinecarboxylic acid

α-methylene-γ-butyrolactone

3-methylbutyric acid

Refernces

• 1、 Shi, Yong,Xiao, Qing,Lan, Quan,Wang, Da-Hai,Jia, Lan-Qi,Tang, Xiao-Hu,Zhou, Tao,Li, Min,Tian, Wei-Sheng. "A synthesis of cephalostatin 1". . p. 1722 - 1738. Retrieved 2019.
• 2、 Kato, Daiki,Kawasaki, Masashi,Morita, Yuko,Okada, Takuya,Tanaka, Yasuo,Toyooka, Naoki. "Synthesis and olfactory evaluation of optically active β-alkyl substituted γ-lactones and whiskey lactone analogues". . . Retrieved 2020/02/22.
• 3、 -. "METHOD FOR REDUCTION OF ORGANIC MOLECULES". Paragraph 0050; 0052; 0053; 0054; 0055. . Retrieved 2018/02/06.