3-(4-fluorophenyl)-2-phenylpropanenitrile

Base Information

• Chemical Name: 3-(4-fluorophenyl)-2-phenylpropanenitrile
• CAS No.: 72035-44-0
• Molecular Formula: C₁₅H₁₂FN
• Molecular Weight: 225.265
• Mol file: 72035-44-0.mol

Synonyms:3-(4-fluorophenyl)-2-phenylpropanenitrile

Chemical Property of 3-(4-fluorophenyl)-2-phenylpropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-fluorophenyl)-2-phenylpropanenitrile

There total 3 articles about 3-(4-fluorophenyl)-2-phenylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-fluorobenzylic alcohol (459-56-3) + phenylacetonitrile (140-29-4) → 3-(4-fluorophenyl)-2-phenylpropanenitrile (72035-44-0)

Guidance literature:

With [(bis(2-dicyclohexylphosphinoethyl)amine)Fe(CO)Br₂]; sodium triethylborohydride; sodium hydroxide; In toluene; at 130 ℃; for 6h; Glovebox; Sealed tube; Inert atmosphere; Flow reactor; High pressure;

DOI:10.1002/chem.201803762

Reference yield: 90.0%

(Z)-3-(4-fluorophenyl)-2-phenylacrylonitrile (37629-63-3) → 3-(4-fluorophenyl)-2-phenylpropanenitrile (72035-44-0)

Guidance literature:

With sodium tetrahydroborate; In N,N-dimethyl-formamide; Ambient temperature; overnight;

DOI:10.1021/jo01289a038

Reference yield:

4-fluorobenzylic alcohol (459-56-3) + phenylacetonitrile (140-29-4) → C15H10FN (324-61-8) + 3-(4-fluorophenyl)-2-phenylpropanenitrile (72035-44-0)

Guidance literature:

With acetonitrile(η5-diethylaminocyclopenyadienyl)bis(triphenylphosphine)ruthenium(II) tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 120 ℃; for 24h; Inert atmosphere;

DOI:10.1039/b917805h

upstream raw materials:

(Z)-3-(4-fluorophenyl)-2-phenylacrylonitrile

4-fluorobenzylic alcohol

phenylacetonitrile

Refernces

• 1、 Roy, Bivas Chandra,Ansari, Istikhar A.,Samim, Sk. Abdus,Kundu, Sabuj. "Base-Promoted α-Alkylation of Arylacetonitriles with Alcohols". supporting information. p. 2215 - 2219. Retrieved 2019/06/13.
• 2、 Li, Junjun,Liu, Yuxuan,Tang, Weijun,Xue, Dong,Li, Chaoqun,Xiao, Jianliang,Wang, Chao. "Atmosphere-Controlled Chemoselectivity: Rhodium-Catalyzed Alkylation and Olefination of Alkylnitriles with Alcohols". supporting information. p. 14445 - 14449. Retrieved 2017/10/07.