Technology Process of 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2,4-dimethoxybenzyl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
There total 8 articles about 2-((4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2,4-dimethoxybenzyl)-5-methylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Cooling with ice
3: sodium hydroxide; ammonium hydroxide; ammonium chloride; sodium hypochlorite; Aliquat 336 / diethyl ether; water; tert-butyl methyl ether / 0 - 20 °C
4: chloroacetyl chloride / acetic acid / 2 h / 20 °C / Cooling with ice
5: pyridinium p-toluenesulfonate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 140 °C
6: potassium carbonate / N,N-dimethyl-formamide / 20 °C
With
ammonium hydroxide; sodium hypochlorite; oxalyl dichloride; pyridinium p-toluenesulfonate; Aliquat 336; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; chloroacetyl chloride; sodium hydroxide;
In
5,5-dimethyl-1,3-cyclohexadiene; diethyl ether; dichloromethane; tert-butyl methyl ether; water; acetic acid; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridinium p-toluenesulfonate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 140 °C
2: potassium carbonate / N,N-dimethyl-formamide / 20 °C
With
pyridinium p-toluenesulfonate; potassium carbonate;
In
5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;