16-DEHYDROPREGNENOLONE OXIME

Base Information

• Chemical Name: 16-DEHYDROPREGNENOLONE OXIME
• CAS No.: 1045-71-2
• Molecular Formula: C21H31NO2
• Molecular Weight: 329.483
• Mol file: 1045-71-2.mol

Synonyms:16-Dehydropregnenolone oxime;

Chemical Property of 16-DEHYDROPREGNENOLONE OXIME

Chemical Property:

• Boiling Point: 489.3 °C at 760 mmHg
• Flash Point: 325.2 °C
• PSA: 52.82000
• Density: 1.24 g/cm³
• LogP: 4.69650

Purity/Quality:

98%,99%, ^*data from raw suppliers

16-DEHYDROPREGNENOLONE OXIME 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 16-DEHYDROPREGNENOLONE OXIME

There total 6 articles about 16-DEHYDROPREGNENOLONE OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3β-acetoxy-20-hydroxyiminopregna-5,16-diene (23549-24-8,23549-26-0,2174-13-2) → 20-hydroxyiminopregna-5,16(20)-dien-3β-ol (1045-71-2)

Guidance literature:

With potassium hydroxide; In methanol; at 70 ℃; for 0.166667h;

DOI:10.1021/jm001008m

Reference yield: 98.0%

16-dehydropregnenolone (1162-53-4) → 20-hydroxyiminopregna-5,16(20)-dien-3β-ol (1045-71-2)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 0.5h; Reflux;

DOI:10.1039/d0ob02344b

Reference yield:

16-dehydropregnenolone acetate (979-02-2) → 20-hydroxyiminopregna-5,16(20)-dien-3β-ol (1045-71-2)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In methanol;

DOI:10.1016/j.molstruc.2013.08.048

upstream raw materials:

16-dehydropregnenolone

3β-acetoxy-20-hydroxyiminopregna-5,16-diene

3β-acetoxy-17-cyano-androsta-5,16-diene

17alpha-ethynyl-3beta,17beta-dihydroxy-androst-5-ene

Downstream raw materials:

3β-acetoxy-20-hydroxyiminopregna-5,16-diene

Refernces

• 1、 Hartmann,Hector,Haidar,Ehmer,Reichert,Jose. "Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17α-hydroxylase/c17-20-lyase) and 5α-reductase types 1 and 2". . p. 4266 - 4277. Retrieved 2000.
• 2、 Lopes, Susana M. M.,Santos, Joana R. C.,Pinho e Melo, Teresa M. V. D.. "Reactivity of steroidal 1-azadienes toward enamines: an approach to novel chiral penta- And hexacyclic steroids". . p. 1122 - 1132. Retrieved 2021/02/16.
• 3、 Sethi, Arun,Maurya, Atul,Tewari, Vibha,Srivastava, Sanjay,Faridi, Shaheen,Bhatia, Gitika,Khan,Khanna,Saxena. "Expeditious and convenient synthesis of pregnanes and its glycosides as potential anti-dyslipidemic and anti-oxidant agents". . p. 4520 - 4527. Retrieved 2008/03/13.