3-Methylpicolinamide

Base Information

• Chemical Name: 3-Methylpicolinamide
• CAS No.: 937648-82-3
• Molecular Formula: C7H8 N2 O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10586360
• Wikidata: Q72495514
• Mol file: 937648-82-3.mol

Synonyms:3-METHYLPICOLINAMIDE;937648-82-3;3-Methylpyridine-2-carboxamide;3-methyl-2-pyridinecarboxamide;2-Pyridinecarboxamide,3-methyl-;3-Methyl-pyridine-2-carboxylic acid amide;methylpyridine carboxamide;SCHEMBL162188;3-methyl-2-pyridine carboxamide;DTXSID10586360;AIOUQYUFHADEHR-UHFFFAOYSA-N;MFCD04108101;AKOS005067601;TS-01750;DB-079681;CS-0172071;A859643;AN-584/40470516;J-512920

Chemical Property of 3-Methylpicolinamide

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 291ºC
• Flash Point: 130 ºC
• PSA: 55.98000
• Density: 1.157
• LogP: 1.18920
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

3-Methylpicolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)C(=O)N

Technology Process of 3-Methylpicolinamide

There total 2 articles about 3-Methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-cyano-3-methylpyridine (20970-75-6) → 3-methyl-2-pyridinecarboxamide (937648-82-3)

Guidance literature:

With sulfuric acid; at 20 - 80 ℃; for 0.416667h;

Reference yield: 44.0%

3-Methylpyridine (108-99-6) + formamide (77287-34-4,77287-35-5,60100-09-6) → 5-methyl-2-pyridinecarboxamide (20970-77-8) + 3-methyl-2-pyridinecarboxamide (937648-82-3)

Guidance literature:

With dipotassium peroxodisulfate; at 70 ℃; for 12h;

DOI:10.1016/j.tetlet.2017.11.006

Reference yield: 87.8%

3-methyl-2-pyridinecarboxamide (937648-82-3) → 3-methylpyridin-2-ylamine (1603-40-3)

Guidance literature:

With sodium hypobromide; water; sodium hydroxide; at 0 - 60 ℃; for 0.5h;

upstream raw materials:

2-cyano-3-methylpyridine

3-Methylpyridine

formamide

Downstream raw materials:

3-methylpyridin-2-ylamine

Refernces

• 1、 -. "New synthesis method of 2-amino-3-methylpyridine". Page/Page column 3-4. . Retrieved 2019/05/15.
• 2、 Ma, Xiaoyun,He, Ying,Lu, Ming. "Efficient Mo(VI)-catalyzed hydration of nitrile with acetaldoxime". supporting information. p. 474 - 480. Retrieved 2014/01/23.