Technology Process of (E)-methyl 5-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenoxy)pentanoate
There total 10 articles about (E)-methyl 5-(2-(3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)phenoxy)pentanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol; ethanol; water;
at 65 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C
2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C
2.2: 2 h / 0 °C
3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 16 h / 80 °C
4.1: toluene-4-sulfonic acid / ethanol; water; methanol / 65 °C
With
hydrogenchloride; iron; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: iodine / water; methanol
2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C
3: zinc; acetic acid / 3 h / 116 °C / Reflux
4: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 16 h / 80 °C
5: toluene-4-sulfonic acid / ethanol; water; methanol / 65 °C
With
iodine; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; zinc;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;