2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid

Base Information

• Chemical Name: 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid
• CAS No.: 1567836-15-0
• Molecular Formula: C₂₈H₂₆N₂O₁₀S₂
• Molecular Weight: 614.654
• Mol file: 1567836-15-0.mol

Synonyms:2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid

Chemical Property of 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid

There total 7 articles about 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate (1567836-16-1) → 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid (1567836-15-0)

Guidance literature:

diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate; With potassium hydroxide; In methanol; water; at 65 ℃; for 2h;

With hydrogenchloride; In methanol; water; pH=3;

DOI:10.1021/jm5000529

Reference yield:

4-methoxy-N-[4-[(4-methoxyphenyl)sulfonylamino]-1-naphthyl]benzenesulfonamide (321694-20-6) → 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid (1567836-15-0)

Guidance literature:

4-methoxy-N-[4-[(4-methoxyphenyl)sulfonylamino]-1-naphthyl]benzenesulfonamide; alkyl bromoacetate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With lithium hydroxide; In methanol; water; for 2h;

DOI:10.1016/j.redox.2020.101565

Reference yield:

N,N'-(naphthalene-1,4-diyl)bis(4-methoxy-N-(2-oxo-2-(2-oxothiazolidin-3-yl)ethyl)benzenesulfonamide) → 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid (1567836-15-0)

Guidance literature:

With dihydrogen peroxide; In aq. phosphate buffer; dimethyl sulfoxide; at 37 ℃; pH=7.4;

DOI:10.1016/j.redox.2020.101565

upstream raw materials:

1,4-diaminonaphthalene

1-amino-4-nitronaphthalene

diethyl 2,2′-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetate

1-Nitronaphthalene

Refernces

• 1、 -. "Keap1-Nrf2 PPI inhibitor prodrug and preparation method and application". . . Retrieved 2021/02/06.
• 2、 Jiang, Zheng-Yu,Xu, Li-Li,Lu, Meng-Chen,Chen, Zhi-Yun,Yuan, Zhen-Wei,Xu, Xiao-Li,Guo, Xiao-Ke,Zhang, Xiao-Jin,Sun, Hao-Peng,You, Qi-Dong. "Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor". . p. 6410 - 6421. Retrieved 2015/09/08.