Thiazolo[4,5-c]quinolin-2-amine

Base Information

• Chemical Name: Thiazolo[4,5-c]quinolin-2-amine
• CAS No.: 143667-61-2
• Molecular Formula: C₁₀H₇N₃S
• Molecular Weight: 201.252
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID60474283
• Wikidata: Q82304170
• Mol file: 143667-61-2.mol

Synonyms:Thiazolo[4,5-c]quinolin-2-amine;143667-61-2;[1,3]thiazolo[4,5-c]quinolin-2-amine;2-AMINOTHIAZOLO[4,5-C]QUINOLINE;AR-527/43363324;SCHEMBL6783425;DTXSID60474283;XNJAINQKRZAMIG-UHFFFAOYSA-N;thiazolo[4,5-c]quinolin-2-yl-amine;AKOS005062873;CS-0328722;FT-0689905;A853330

Chemical Property of Thiazolo[4,5-c]quinolin-2-amine

Chemical Property:

• PSA: 80.04000
• LogP: 3.00790
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 201.03606841
• Heavy Atom Count: 14
• Complexity: 223

Purity/Quality:

98%min ^*data from raw suppliers

2-Aminothiazolo[4,5-c]quinoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(C=N2)N=C(S3)N

Technology Process of Thiazolo[4,5-c]quinolin-2-amine

There total 4 articles about Thiazolo[4,5-c]quinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromocyane (506-68-3) → SKA-56 (143667-61-2)

Guidance literature:

With water;

DOI:10.1021/ja01194a060

Reference yield:

3-aminoquinoline (580-17-6) + potassium thioacyanate (333-20-0) → SKA-56 (143667-61-2)

Guidance literature:

With methanol; acetic acid; anschliessend Behandeln mit Brom in Essigsaeure, zuletzt bei 100grad;

DOI:10.1021/ja01156a103

Reference yield:

3-aminoquinoline (580-17-6) + ammonium thiocyanate (1147550-11-5) → SKA-56 (143667-61-2)

Guidance literature:

With bromine; In methanol; for 0.5h; Yield given; Ambient temperature;

DOI:10.1055/s-1992-26191

upstream raw materials:

3-aminoquinoline

potassium thioacyanate

ammonium thiocyanate

3-amino-4-mercapto-quinoline

Downstream raw materials:

2H-2-Phenyl<1,4>thiazino<3,2-c>quinolin-3(4H)-one

3-amino-4-mercapto-quinoline

Refernces

• 1、 Ambrogi,Grandolini,Perioli,Rossi. "Convenient synthesis of 2-aminonaphthalene-1-thiol and 3-aminoquinoline-4-thiol and cyclocondensations to 1,4-thiazino and 1,4-thiazepino derivatives". . p. 656 - 658. Retrieved 2007/10/02.