1-BOC-3-BROMOMETHYLPIPERIDINE

Base Information

• Chemical Name: 1-BOC-3-BROMOMETHYLPIPERIDINE
• CAS No.: 193629-39-9
• Molecular Formula: C11H20 Br N O2
• Molecular Weight: 278.189
• Hs Code.: 2933399090
• Mol file: 193629-39-9.mol

Synonyms:1-Boc-3-bromomethylpiperidine;3-Bromomethylpiperidine-1-carboxylic acid tert-butyl ester; tert-Butyl3-(bromomethyl)piperidine-1-carboxylate

Chemical Property of 1-BOC-3-BROMOMETHYLPIPERIDINE

Chemical Property:

• Vapor Pressure: 0.000363mmHg at 25°C
• Boiling Point: 318.3 ºC at 760 mmHg
• PKA: -2.03±0.40(Predicted)
• Flash Point: 146.3 ºC
• PSA: 29.54000
• Density: 1.27 g/cm³
• LogP: 2.96630
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl3-(bromomethyl)piperidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-3-BROMOMETHYLPIPERIDINE

There total 2 articles about 1-BOC-3-BROMOMETHYLPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.7%

(±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (116574-71-1) → 1,1-dimethylethyl 3-(bromomethyl)-1-piperidinecarboxylate (193629-39-9)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃;

Reference yield:

3-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester (162166-99-6) → 1,1-dimethylethyl 3-(bromomethyl)-1-piperidinecarboxylate (193629-39-9)

Guidance literature:

With lithium bromide; In acetone; Reflux;

Reference yield: 97.0%

1,1-dimethylethyl 3-(bromomethyl)-1-piperidinecarboxylate (193629-39-9) + N-(4-methoxy-2-phenylphenyl)benzensulfonamide → t-butyl-3-[[N-(benzenesulfonyl)-4-methoxy-2-phenylanilino]methyl]piperidine-1-carboxylate

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 0.166667h; Microwave irradiation;

upstream raw materials:

(±)-tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate

3-methanesulfonyloxymethyl-piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

3-iodomethylpiperidine-1-carboxylic acid tert-butyl ester

2-(3,5-dichlorophenyl)-4-(N-boc-3-piperidinemethyl)-thiophene[2,3-d]pyridazine-7-carboxylic acid ethyl ester

Refernces

• 1、 -. "4 - Amino - pyrimidine and nitrogen heterocyclic derivatives and its preparation and use (by machine translation)". . . Retrieved 2019/10/02.