BOC-3-FLUORO-4-OXOPYRROLIDINE

Base Information

• Chemical Name: BOC-3-FLUORO-4-OXOPYRROLIDINE
• CAS No.: 845894-03-3
• Molecular Formula: C9H14FNO3
• Molecular Weight: 203.21
• Hs Code.: 2933990090
• Mol file: 845894-03-3.mol

Synonyms:3-Fluoro-4-oxopyrrolidine-1-carboxylicacid tert-butyl ester;1-Boc-3-fluoro-4-pyrrolidinone;

Chemical Property of BOC-3-FLUORO-4-OXOPYRROLIDINE

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.00717mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 269.6 ºC at 760 mmHg
• Flash Point: 116.9 ºC
• PSA: 46.61000
• Density: 1.18 g/cm³
• LogP: 1.08220
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Boc-3-fluoro-4-oxopyrrolidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Boc-3-fluoro-4-pyrrolidinone is used as an intermediate in the manufacture of various substances such as pharmaceuticals, agrochemicals and dyestuffs.

Technology Process of BOC-3-FLUORO-4-OXOPYRROLIDINE

There total 2 articles about BOC-3-FLUORO-4-OXOPYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-3-fluoro-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester (1174020-49-5,1174020-51-9,2055223-76-0,1174020-50-8,1174020-48-4) → tert-butyl 3-fluoro-4-oxopyrrolidine-1-carboxylate (845894-03-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃;

Reference yield:

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) → tert-butyl 3-fluoro-4-oxopyrrolidine-1-carboxylate (845894-03-3)

Guidance literature:

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester; With triethylsilyl chloride; sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1.5h;

In acetonitrile; at 0 ℃;

Reference yield:

tert-butyl 3-fluoro-4-oxopyrrolidine-1-carboxylate (845894-03-3) + 2,4-dichloro-benzenemethanamine (95-00-1) → 3-(2,4-dichlorobenzylamino)-4-fluoropyrrolidine-1-carboxylic acid tert-butyl ester (885102-31-8)

Guidance literature:

tert-butyl 3-fluoro-4-oxopyrrolidine-1-carboxylate; 2,4-dichloro-benzenemethanamine; With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

With sodium hydroxide; In water; 1,2-dichloro-ethane;

upstream raw materials:

trans-3-fluoro-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

3-(2,4-dichlorobenzylamino)-4-fluoropyrrolidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "Mitotic kinesin inhibitors". Page/Page column 35-36. . Retrieved 2010/11/25.