7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione

Base Information

• Chemical Name: 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione
• CAS No.: 57801-82-8
• Molecular Formula: C₁₃H₈BrClN₂S₂
• Molecular Weight: 371.709
• Mol file: 57801-82-8.mol

Synonyms:7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione

Chemical Property of 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione

There total 6 articles about 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one (40017-65-0) → 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione (57801-82-8)

Guidance literature:

With tetraphosphorus decasulfide; In pyridine; at 70 - 75 ℃; for 2.5h;

DOI:10.1135/cccc19840621

Reference yield:

2-Amino-3-(o-chlorobenzoyl)-thiophene (40017-58-1) → 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione (57801-82-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 43 percent / CHCl₃ / 1) after mixing slowly heated and refluxed 2 h, 2) standing overnight

2: 58 percent / hydrazine hydrate / methanol; CHCl₃; H₂O / 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight

3: 13 percent / acetic acid / benzene; pyridine / 5.5 h / Heating

4: 86 percent / bromine, pyridine / CHCl₃ / 3.75 h / 20 - 24 °C

5: 85 percent / P₂S₅ / pyridine / 2.5 h / 70 - 75 °C

With pyridine; tetraphosphorus decasulfide; bromine; hydrazine hydrate; acetic acid; In pyridine; methanol; chloroform; water; benzene;

DOI:10.1135/cccc19840621

Reference yield:

3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene (53265-13-7) → 7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-thione (57801-82-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 58 percent / hydrazine hydrate / methanol; CHCl₃; H₂O / 1) 45 deg C, 10 min, 2) 60 deg C, 1,5 h, 3) standing overnight

2: 13 percent / acetic acid / benzene; pyridine / 5.5 h / Heating

3: 86 percent / bromine, pyridine / CHCl₃ / 3.75 h / 20 - 24 °C

4: 85 percent / P₂S₅ / pyridine / 2.5 h / 70 - 75 °C

With pyridine; tetraphosphorus decasulfide; bromine; hydrazine hydrate; acetic acid; In pyridine; methanol; chloroform; water; benzene;

DOI:10.1135/cccc19840621

upstream raw materials:

7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

2-Amino-3-(o-chlorobenzoyl)-thiophene

3-(2-Chlorobenzoyl)-2-(phtalimidoacetamido)thiophene

2-amino-N-[3-(2-chlorobenzoyl)thiophen-2-yl]acetamide

Downstream raw materials:

2-Bromo-4-(2-chlorophenyl)-6H-thieno<3,2-f>-1,2,4-triazolo<4,3-a>-1,4-diazepine

7-Bromo-5-(2-chlorophenyl)-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

7-Bromo-5-(2-chlorophenyl)-2-hydrazino-1,3-dihydrothieno<2,3-e>-1,4-diazepin-2-one

2-bromo-4-(2-chlorophenyl)-9-hydroxymethyl-6H-thieno-<3,2-f>-1,2,4-triazolo-<4,3-a>-1,4-diazepine

Refernces