N-Boc-trans-4-fluoro-L-proline

Base Information Edit

Chemical Name:N-Boc-trans-4-fluoro-L-proline
CAS No.:203866-14-2
Molecular Formula:C10H16FNO4
Molecular Weight:233.24
Hs Code.:29339900
European Community (EC) Number:633-845-4
DSSTox Substance ID:DTXSID70476394
Nikkaji Number:J932.819J
Wikidata:Q72449297
Mol file:203866-14-2.mol

Synonyms:203866-14-2;N-Boc-trans-4-fluoro-L-proline;(2S,4R)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid;2085759-54-0;(2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid;(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid;Boc-trans-4-Fluoro-L-proline;(2S,4R)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid;MFCD06796085;C10H16FNO4;rel-(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid;(2S,4R)-4-fluoro-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester;1,2-PYRROLIDINEDICARBOXYLIC ACID, 4-FLUORO-, 1-(1,1-DIMETHYLETHYL) ESTER, (2S,4R)-;Boc-Pro(4-F)-OH;(2S,4R)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid;(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboyxlic acid;SCHEMBL192501;(2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylic acid;(2S,4R)-N-Boc-4-fluoropyrrolidine-2-carboxylic acid;DTXSID70476394;YGWZXQOYEBWUTH-RQJHMYQMSA-N;AKOS005762889;N-Boc-trans-4-fluoro-L-proline, 97%;(1,1-dimethylethyl) ester, (2S,4R)-;AC-14450;AS-39510;AM20090157;B3177;CS-0039074;EN300-210429;(4r)-1-(tert-butoxycarbonyl)-4-fluoro-l-proline;1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-;A814512;N-(tert-Butoxycarbonyl)-trans-4-fluoro-L-proline;Q-102833;(2S,4R)-1-(Boc)-4-fluoropyrrolidine-2-carboxylic acid;(2S,4R)-1-(tert-butoxycarbonyl)-4-fluoropyrro lidine-2-carboxylic acid;(2S,4R)-1-tert-butoxycarbonyl-4-fluoro-pyrrolidine-2-carboxylic acid

Suppliers and Price of N-Boc-trans-4-fluoro-L-proline

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
N-Boc-trans-4-fluoro-L-proline
500mg
$ 347.00

TCI Chemical
(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >96.0%(GC)(T)
200mg
$ 59.00

TCI Chemical
(2S,4R)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >96.0%(GC)(T)
1g
$ 202.00

SynQuest Laboratories
N-Boc-trans-4-fluoro-L-proline
5 g
$ 650.00

SynQuest Laboratories
N-Boc-trans-4-fluoro-L-proline
1 g
$ 175.00

Sigma-Aldrich
N-Boc-trans-4-fluoro-L-proline 97%
500mg
$ 153.00

Matrix Scientific
Boc-trans-4-Fluoro-L-proline
500mg
$ 177.00

Matrix Scientific
Boc-trans-4-Fluoro-L-proline
1g
$ 258.00

Iris Biotech GmbH
Boc-L-Pro(4-F)-OH(2S,4R)
5 g
$ 270.00

Frontier Specialty Chemicals
N-Boc-trans-4-fluoro-L-proline 98%
250mg
$ 90.00

Total 85 raw suppliers

Chemical Property of N-Boc-trans-4-fluoro-L-proline Edit

Chemical Property:

Vapor Pressure:1.05E-05mmHg at 25°C
Melting Point:115-119 °C
Refractive Index:-69 ° (C=1, MeOH)
Boiling Point:346 °C at 760 mmHg
PKA:3.53±0.40(Predicted)
Flash Point:163 °C
PSA：66.84000
Density:1.24 g/cm³
LogP:1.35640
Storage Temp.:Inert atmosphere,Room Temperature
Solubility.:soluble in Methanol
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:233.10633615
Heavy Atom Count:16
Complexity:300

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-trans-4-fluoro-L-proline ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(CC1C(=O)O)F
Isomeric SMILES:CC(C)(C)OC(=O)N1C[C@@H](C[C@H]1C(=O)O)F
Uses N-Boc-trans-4-fluoro-L-proline is a useful synthetic intermediate. It is used to prepare potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors. It is also used to synthesize pyrrolotriazines derivatives as pan-Aurora kinase inhibitors and anti-tumor agents.

Technology Process of N-Boc-trans-4-fluoro-L-proline

There total 14 articles about N-Boc-trans-4-fluoro-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%