(Z)-(3)-IODOACRYLIC ACID

Base Information

• Chemical Name: (Z)-(3)-IODOACRYLIC ACID
• CAS No.: 6214-35-3
• Molecular Formula: C3H3IO2
• Molecular Weight: 197.96
• Hs Code.: 2916190090
• Mol file: 6214-35-3.mol

Synonyms:2-Propenoicacid, 3-iodo-, (Z)-;Acrylic acid, 3-iodo-, (Z)- (8CI);(Z)-3-Iodo-2-propenoicacid;(Z)-3-Iodoacrylic acid;(2Z)-3-Iodoprop-2-enoic acid;

Chemical Property of (Z)-(3)-IODOACRYLIC ACID

Chemical Property:

• Appearance/Colour: White to yellow crystalline powder
• Vapor Pressure: 0.00783mmHg at 25°C
• Melting Point: 65 °C
• Refractive Index: 1.636
• Boiling Point: 248.3 °C at 760 mmHg
• Flash Point: 104 °C
• PSA: 37.30000
• Density: 2.325 g/cm³
• LogP: 1.01970
• Storage Temp.: 2-8°C

Purity/Quality:

99.90% ^*data from raw suppliers

cis-3-Iodoacrylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Z)-(3)-IODOACRYLIC ACID

There total 9 articles about (Z)-(3)-IODOACRYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

Propiolic acid (471-25-0) → (Z)-3-iodoprop-2-enoic acid (6214-35-3)

Guidance literature:

With hydrogen iodide; In water; at 50 ℃; for 17h;

DOI:10.1016/j.cclet.2021.12.050

Reference yield: 91.0%

Propiolic acid (471-25-0) → (Z)-3-iodoprop-2-enoic acid (6214-35-3) + (E)-3-iodoacrylic acid (6372-02-7)

Guidance literature:

With hydrogen iodide; In water; at 80 - 85 ℃; Yields of byproduct given;

DOI:10.1016/S0040-4039(98)01434-8

Reference yield:

(E)-3-iodoacrylic acid (6372-02-7) → (Z)-3-iodoprop-2-enoic acid (6214-35-3)

Guidance literature:

With hydrogen iodide; In benzene; Reflux;

DOI:10.1021/ol1029996

upstream raw materials:

1,1,3,3-tetraiodo-propan-2-one

Propiolic acid

methyl iodide

(E)-3-iodoacrylic acid

Downstream raw materials:

methyl (2Z)-3-iodoprop-2-enoate

(E)-methyl 3-iodoacrylate

(E)-3-iodoacrylic acid

(Z)-penta-2,4-dienoic acid

Refernces

• 1、 Jung, Michael E.,Hagenah, Jeffrey A.,Long-Mei, Zeng. "SIMPLE, STEREOSPECIFIC PREPARATION OF Z-3-IODOACRYLIC ACID FROM PROPIOLIC ACID AND METHYLMAGNESIUM IODIDE". . p. 3973 - 3974. Retrieved 1983.
• 2、 Chu, Lingling,Dai, Yubei,Wang, Fang,Zhu, Shengqing. "Selective Ni-catalyzed cross-electrophile coupling of alkynes, fluoroalkyl halides, and vinyl halides". supporting information. . Retrieved 2022/01/26.
• 3、 -. "AMINOMETHYLAMIDINE AND METHYLAMIDINE ANTIMICROBIAL COMPOUNDS". Page/Page column 173. . Retrieved 2019/12/28.