Isobutylmagnesium Bromide

Base Information

• Chemical Name: Isobutylmagnesium Bromide
• CAS No.: 926-62-5
• Molecular Formula: C4H9BrMg
• Molecular Weight: 161.324
• Hs Code.: 29319090
• European Community (EC) Number: 627-136-9
• Mol file: 926-62-5.mol

Synonyms:Isobutylmagnesium Bromide;926-62-5;Magnesium,bromo(2-methylpropyl)-;Bromoisobutylmagnesium;Isobutylmagnesium bromide, 1.0 M in THF;Bromoisobutylmagnesim;isobutylmagnesiumbromide;bromo(isobutyl)magnesium;iso-butymagnesium bromide;isobutyl magnesium bromide;isobutyl-magnesium bromide;Iso-butyl magnesium bromide;2-methylpropylmagnesiumbromide;SCHEMBL116706;bromo(2-methylpropyl)magnesium;ISO-BUTYLMAGNESIUM BROMIDE;CMWBEISSZHZIMU-UHFFFAOYSA-M;MFCD00075126;AKOS015902635;Isobutylmagnesium bromide, 1.0 M in 2-MeTHF;J-802228;Isobutylmagnesium Bromide (17% in Tetrahydrofuran, ca. 1mol/L);ISOBUTYLMAGNESIUM BROMIDE (17% IN TETRAHYDROFURAN, CA. 1MOL /L)

Chemical Property of Isobutylmagnesium Bromide

Chemical Property:

• Melting Point: 51-53℃
• Boiling Point: 122-123℃ (0.2 Torr)
• Flash Point: <−30 °F
• PSA: 0.00000
• Density: 0.941 g/mL at 25 °C
• LogP: 2.45560
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 159.97380
• Heavy Atom Count: 6
• Complexity: 15

Purity/Quality:

98%,99%, ^*data from raw suppliers

IsobutylmagnesiumBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F+；C
• Hazard Codes: F+,C,Xn
• Statements: 12-14/15-19-22-34-67-66
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)[CH2-].[Mg+2].[Br-]
• Uses: Isobutylmagnesium bromide (iBuMgBr) is a general Grignard reagent used in the total synthesis of (+)-rishirilide B, glucolipsin A, and (+)-juvabione. It can also be used as a reagent in the synthesis of pyrrolidine-based influenza neuraminidase (NA) inhibitors.

Technology Process of Isobutylmagnesium Bromide

There total 6 articles about Isobutylmagnesium Bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Isobutyl bromide (78-77-3) → isobutylmagnesium bromide (926-62-5)

Guidance literature:

With iodine; magnesium; In diethyl ether; for 0.75h; Inert atmosphere; Cooling with ice; Reflux;

DOI:10.1016/j.bmcl.2016.07.010

Reference yield:

2-acetyl-3-t-butyloxycarbonyl-aminothiophene + Isobutyl bromide (78-77-3) + ammonium chloride → isobutylmagnesium bromide (926-62-5)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield:

Isobutyl bromide (78-77-3) → isobutylmagnesium bromide (926-62-5)

Guidance literature:

With carbon disulfide; diethyl ether;

upstream raw materials:

Isobutyl bromide

di-iso-butylmagnesium

Downstream raw materials:

20-Isobutyl-5α-pregnanon-(16)

P(i-C4H9)3O

3-(2-methylpropyl)cyclohexene

2,9-dimethyldeca-5-yne

Refernces

• 1、 Bueno, José María,Carda, Miguel,Crespo, Benigno,Cu?at, Ana Carmen,de Cozar, Cristina,León, María Luisa,Marco, J. Alberto,Roda, Nuria,Sanz-Cervera, Juan F.. "Design, synthesis and antimalarial evaluation of novel thiazole derivatives". supporting information. p. 3938 - 3944. Retrieved 2016/08/01.
• 2、 Novakov,Feierman,Cederbaum,Stoyanovsky. "An ESR and HPLC-EC assay for the detection of alkyl radicals". . p. 1239 - 1246. Retrieved 2007/10/03.