1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE

Base Information

• Chemical Name: 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE
• CAS No.: 385425-15-0
• Molecular Formula: C11H12 I N O
• Molecular Weight: 301.127
• Mol file: 385425-15-0.mol

Synonyms:1-(4-Iodophenyl)-2-piperidinone

Chemical Property of 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE

Chemical Property:

• Boiling Point: 446.1±28.0 °C(Predicted)
• PKA: -0.43±0.20(Predicted)
• PSA: 20.31000
• Density: 1.670
• LogP: 2.87310
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Iodophenyl)piperidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE

There total 9 articles about 1-(4-IODO-PHENYL)-PIPERIDIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-chloro-N-(4-iodophenyl) pentanamide → 1-(2-oxopiperidin-1-yl)-4-iodobenzene (385425-15-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 80 ℃;

Reference yield: 81.0%

5-bromovaleroyl chloride (4509-90-4) + p-aminoiodobenzene (540-37-4) → 1-(2-oxopiperidin-1-yl)-4-iodobenzene (385425-15-0)

Guidance literature:

5-bromovaleroyl chloride; p-aminoiodobenzene; With triethylamine; In tetrahydrofuran; at 20 ℃;

With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Further stages.;

DOI:10.1021/jm070245n

Reference yield: 79.0%

5-bromo-pentanoic acid-(4-iodophenyl)amide → 1-(2-oxopiperidin-1-yl)-4-iodobenzene (385425-15-0)

Guidance literature:

With potassium phosphate; In N,N-dimethyl-formamide; toluene; at 110 ℃; for 7h; Solvent;

upstream raw materials:

5-bromovaleroyl chloride

p-aminoiodobenzene

5-bromopentanoic acid

N-phenyl piperidine

Downstream raw materials:

1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid

5,6?dihydro?3?(4?morpholinyl)?1?[4?(2?oxo?1?piperidinyl)phenyl]?2(1H)?pyridone

1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester

Refernces

• 1、 -. "AN IMPROVED PROCESS FOR THE PREPARATION OF APIXABAN". Page/Page column 11. . Retrieved 2017/12/09.
• 2、 -. "Pyrazolo [3, 4 - c] pyridine - 7 - ketone compound and use thereof". . . Retrieved 2017/09/01.