Technology Process of (Z)-2-(4-oxo-5-(carbomethoxy)pentylidene)cyclohexanol
There total 12 articles about (Z)-2-(4-oxo-5-(carbomethoxy)pentylidene)cyclohexanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 86 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C
2: 1.) phosphorus oxychloride, HMPA, 2.) pyridine / 1.) room temperature -> 50 deg C, 2.) 50 deg C -> 100 deg C
3: 83 percent / DIBAL-H / hexane; tetrahydrofuran / -78 °C
4: 60 percent / 48percent fluoboric acid / diethyl ether / 1.17 h
5: 184 mg / lithium diisopropyl amide / diethyl ether / 2 h / -78 °C
6: MCPBA, 0.5 M sodium bicarbonate / CH2Cl2 / 5 h / 0 °C
7: magnesium methoxide / methanol / Ambient temperature
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; tetrafluoroboric acid; diisobutylaluminium hydride; sodium hydrogencarbonate; magnesium methanolate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane;
DOI:10.1021/ja00547a015
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 184 mg / lithium diisopropyl amide / diethyl ether / 2 h / -78 °C
2: MCPBA, 0.5 M sodium bicarbonate / CH2Cl2 / 5 h / 0 °C
3: magnesium methoxide / methanol / Ambient temperature
With
sodium hydrogencarbonate; magnesium methanolate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja00547a015
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / DIBAL-H / toluene / 1.) -78 deg C, 30 min, 2.) 0 deg C, 2 h
2: 70 percent / 48percent fluoboric acid / diethyl ether
3: 184 mg / lithium diisopropyl amide / diethyl ether / 2 h / -78 °C
4: MCPBA, 0.5 M sodium bicarbonate / CH2Cl2 / 5 h / 0 °C
5: magnesium methoxide / methanol / Ambient temperature
With
tetrafluoroboric acid; diisobutylaluminium hydride; sodium hydrogencarbonate; magnesium methanolate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
methanol; diethyl ether; dichloromethane; toluene;
DOI:10.1021/ja00547a015