methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate

Base Information

• Chemical Name: methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate
• CAS No.: 13305-16-3
• Molecular Formula: C₁₁H₁₄O₄
• Molecular Weight: 210.23
• Mol file: 13305-16-3.mol

Synonyms:methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate

Chemical Property of methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate

There total 24 articles about methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-(4-methoxybenzoyl)acetate (22027-50-5) → (S)-(-)-methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate (13305-16-3,135505-14-5,39169-57-8)

Guidance literature:

With hydrogen; In methanol; at 50 ℃; for 24h; under 31029.7 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1039/c2cc31247f

Reference yield: 91.0%

methyl 3-(4-methoxybenzoyl)acetate (22027-50-5) → methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate (13305-16-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at -30 ℃; for 1h;

DOI:10.1248/cpb.41.643

Reference yield: 85.0%

4-methoxy-benzaldehyde (123-11-5) + bromoacetic acid methyl ester (96-32-2) → methyl 3-(4-methoxyphenyl)-3-hydroxypropanoate (13305-16-3)

Guidance literature:

With zinc; In benzine; at 80 ℃; for 6h; Inert atmosphere;

upstream raw materials:

methyl 3-(4-methoxybenzoyl)acetate

methanol

acetic acid methyl ester

4-methoxy-benzaldehyde

Downstream raw materials:

3-(4-methoxy-phenyl)acrylic acid methyl ester

methyl 3-(acetyloxy)-3-(4-methoxyphenyl)propanoate

(R)-(+)-methyl 3-(acetyloxy)-3-(4-methoxyphenyl)propanoate

(3R) methyl β-hydroxy-β-(p-methoxyphenyl) propionate

Refernces

• 1、 Wei, De-Quan,Chen, Xiu-Shuai,Hou, Chuan-Jin,Hu, Xiang-Ping. "Iridium-catalyzed asymmetric hydrogenation of β-keto esters with new phenethylamine-derived tridentate P,N,N-ligands". . p. 237 - 243. Retrieved 2019.
• 2、 -. "On the basis of the phenethylamine skeleton chiral P, N, N ligand compound and its manufacturing method and application (by machine translation)". Paragraph 0105; 0115; 0116; 0153-0158; 0160. . Retrieved 2019/06/13.