lapatinib citric acid salt

Base Information

• Chemical Name: lapatinib citric acid salt
• CAS No.: 1092929-12-8
• Molecular Formula: C₆H₈O₇*C₂₉H₂₆ClFN₄O₄S
• Molecular Weight: 773.193
• Mol file: 1092929-12-8.mol

Synonyms:lapatinib citric acid salt

Chemical Property of lapatinib citric acid salt

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of lapatinib citric acid salt

There total 2 articles about lapatinib citric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.2%

lapatanib (231277-92-2) + citric acid (77-92-9,906507-37-7) → lapatinib citric acid salt (1092929-12-8)

Guidance literature:

In methanol; for 1h; Concentration; Solvent; Temperature; Reflux;

Reference yield:

lapatinib ditosylate (388082-78-8,388082-77-7) → lapatinib citric acid salt (1092929-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethyl acetate / 1 h / 20 °C

1.2: 1 h

2.1: methanol / 1 h / Reflux

In methanol; ethyl acetate;

upstream raw materials:

lapatanib

citric acid

lapatinib ditosylate

Refernces

• 1、 -. "QUINAZOLINE SALT COMPOUNDS". Page/Page column 69. . Retrieved 2009/01/24.