Boc-[N-MeβAla]-o-Bzl

Base Information

• Chemical Name: Boc-[N-MeβAla]-o-Bzl
• CAS No.: 344609-41-2
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• Mol file: 344609-41-2.mol

Synonyms:Boc-[N-MeβAla]-o-Bzl

Chemical Property of Boc-[N-MeβAla]-o-Bzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-[N-MeβAla]-o-Bzl

There total 4 articles about Boc-[N-MeβAla]-o-Bzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(tert-butoxycarbonyl)-N-methyl-L-alanine (16948-16-6) → Boc-[N-MeβAla]-o-Bzl (344609-41-2)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

N-(tert-butoxycarbonyl)-N-methyl-L-alanine (16948-16-6) + benzyl bromide (100-39-0) → Boc-[N-MeβAla]-o-Bzl (344609-41-2)

Guidance literature:

With lithium carbonate; In N,N-dimethyl-formamide; Yield given;

DOI:10.1016/S0040-4039(98)01599-8

Reference yield:

L-N-Boc-Ala (15761-38-3) → Boc-[N-MeβAla]-o-Bzl (344609-41-2)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran

2: Li₂CO₃ / dimethylformamide

With lithium carbonate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(98)01599-8

upstream raw materials:

N-(tert-butoxycarbonyl)-N-methyl-L-alanine

benzyl bromide

L-N-Boc-Ala

di-tert-butyl dicarbonate

Downstream raw materials:

N^α-methylalanine benzyl ester

Refernces

• 1、 Calimsiz, Selcuk,Ramos, Angel I. Morales,Lipton, Mark A.. "Solid-phase synthesis and configurational reassigment of callipeltin E. Implications for the structures of callipeltins A and B". . p. 6351 - 6356. Retrieved 2007/10/03.
• 2、 Li, Wen-Ren,Peng, Shao-Zheng. "Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors". . p. 7373 - 7376. Retrieved 2007/10/03.