2-nitro-5-trifluoromethylphenyl methoxymethyl ether

Base Information

• Chemical Name: 2-nitro-5-trifluoromethylphenyl methoxymethyl ether
• CAS No.: 209688-18-6
• Molecular Formula: C₉H₈F₃NO₄
• Molecular Weight: 251.162
• Mol file: 209688-18-6.mol

Synonyms:2-nitro-5-trifluoromethylphenyl methoxymethyl ether

Chemical Property of 2-nitro-5-trifluoromethylphenyl methoxymethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitro-5-trifluoromethylphenyl methoxymethyl ether

There total 1 articles about 2-nitro-5-trifluoromethylphenyl methoxymethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-5-trifluoromethylphenol (402-17-5) + chloromethyl methyl ether (107-30-2) → 2-nitro-5-trifluoromethylphenyl methoxymethyl ether (209688-18-6)

Guidance literature:

DOI:10.1016/j.bmc.2006.06.067

Reference yield: 88.0%

2-nitro-5-trifluoromethylphenyl methoxymethyl ether (209688-18-6) → 2-(methoxymethoxy)-4-(trifluoromethyl)aniline (209688-19-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 1h;

DOI:10.1016/j.bmc.2006.06.067

Reference yield:

2-nitro-5-trifluoromethylphenyl methoxymethyl ether (209688-18-6) → 4-{[2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzamide (913078-80-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / hydrogen / palladium on carbon / methanol / 1 h

2: 92 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 63 percent / potassium carbonate / dimethylformamide / 80 °C

4: 94 percent / HCl / methanol; dioxane / 6 h

5: 88 percent / potassium carbonate / dimethylformamide / 1.5 h / 70 °C

With pyridine; hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.06.067

upstream raw materials:

2-nitro-5-trifluoromethylphenol

chloromethyl methyl ether

Downstream raw materials:

2-(methoxymethoxy)-4-(trifluoromethyl)aniline

N-[2-(methoxymethoxy)-4-(trifluoromethyl)phenyl]-5-methylfuran-2-sulfonamide

N-[2-hydroxy-4-(trifluoromethyl)phenyl]-N-isobutyl-5-methylfuran-2-sulfonamide

N-isobutyl-N-[2-(methoxymethoxy)-4-(trifluoromethyl)phenyl]-5-methylfuran-2-sulfonamide

Refernces

• 1、 -. "Sulfonamide and carboxamide derivatives and drugs containing the same as the active ingredient". . . Retrieved 2008/06/13.