4-CHLOROPHENYLBORONIC ACID PROPANEDIOL ESTER

Base Information

• Chemical Name: 4-CHLOROPHENYLBORONIC ACID PROPANEDIOL ESTER
• CAS No.: 373384-13-5
• Molecular Formula: C9H10BClO2
• Molecular Weight: 196.441
• Mol file: 373384-13-5.mol

Synonyms:4-Chlorophenylboronic acid propanediol ester;4-(1,3,2-Dioxaborinan-2-yl)chlorobenzene;

Chemical Property of 4-CHLOROPHENYLBORONIC ACID PROPANEDIOL ESTER

Chemical Property:

• Vapor Pressure: 0.000836mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 308.8 °C at 760 mmHg
• Flash Point: 140.5 °C
• PSA: 18.46000
• Density: 1.18 g/cm³
• LogP: 1.47210

Purity/Quality:

99% ^*data from raw suppliers

4-(1,3,2-DIOXABORINAN-2-YL)CHLOROBENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLOROPHENYLBORONIC ACID PROPANEDIOL ESTER

There total 1 articles about 4-CHLOROPHENYLBORONIC ACID PROPANEDIOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-Chlorophenylboronic acid (1679-18-1) + trimethyleneglycol (504-63-2) → 2-(4-chlorophenyl)-1,3,2-dioxaborinane (373384-13-5)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1021/ol300627p

Reference yield: 74.0%

2-(4-chlorophenyl)-1,3,2-dioxaborinane (373384-13-5) + 3,5-dimethylphenyl isocyanate (54132-75-1) → N-(3,5-dimethylphenyl)-4-chlorobenzamide (127292-04-0)

Guidance literature:

With copper(l) iodide; lithium tert-butoxide; In N,N-dimethyl-formamide; at 140 ℃; for 16h; Inert atmosphere;

DOI:10.1039/c5gc01374g

Reference yield: 64.0%

N-benzyl-3-phenylpyridine-2-amine (1294517-65-9) + 2-(4-chlorophenyl)-1,3,2-dioxaborinane (373384-13-5) → N-{[4-chlorophenyl](phenyl)methyl}-3-phenylpyridin-2-amine (1416556-09-6)

Guidance literature:

With 3,3-dimethyl-butan-2-one; dodecacarbonyl-triangulo-triruthenium; at 140 ℃; for 36h; Inert atmosphere;

DOI:10.1021/jo302547q

upstream raw materials:

4-Chlorophenylboronic acid

trimethyleneglycol

Downstream raw materials:

N-((4-chlorophenyl)(phenyl)methyl)-3-methylpyridin-2-amine

N-{[4-chlorophenyl](phenyl)methyl}-3-phenylpyridin-2-amine

N-[(4-chlorophenyl)(p-tolyl)methyl]-3-methylpyridin-2-amine

methyl 4-amino-6-(4-chlorophenyl)-3-methoxypicolinate

Refernces

• 1、 Oda, Susumu,Yamamoto, Hisashi. "Generation of organolithium compounds bearing super silyl ester and their application to Matteson rearrangement". supporting information. p. 8165 - 8168. Retrieved 2013/08/23.