2-CHLOROPHENYL TRIFLUOROMETHANESULFONATE

Base Information

• Chemical Name: 2-CHLOROPHENYL TRIFLUOROMETHANESULFONATE
• CAS No.: 66107-36-6
• Molecular Formula: C7H4 Cl F3 O3 S
• Molecular Weight: 260.621
• Hs Code.: 2906299090
• Mol file: 66107-36-6.mol

Synonyms:Methanesulfonicacid, trifluoro-, 2-chlorophenyl ester (9CI); 2-Chlorophenyl triflate; 2-Chlorophenyltrifluoromethanesulfonate

Chemical Property of 2-CHLOROPHENYL TRIFLUOROMETHANESULFONATE

Chemical Property:

• Vapor Pressure: 0.0114mmHg at 25°C
• Refractive Index: 1.4560-1.4600
• Boiling Point: 270.4oC at 760 mmHg
• Flash Point: 117.3oC
• PSA: 51.75000
• Density: 1.6g/cm3
• LogP: 3.64920

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chlorophenyl Trifluoromethanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLOROPHENYL TRIFLUOROMETHANESULFONATE

There total 4 articles about 2-CHLOROPHENYL TRIFLUOROMETHANESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2-monochlorophenol (95-57-8) → 2-chlorophenyl triflate (66107-36-6)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 22h;

DOI:10.1002/anie.200800750

Reference yield: 79.0%

trifluorormethanesulfonic acid (1493-13-6) + 2-chlorobenzenediazonium tetrafluoroborate (1956-97-4) → 2-chlorophenyl triflate (66107-36-6)

Guidance literature:

at 160 ℃; for 1h;

Reference yield: 73.0%

trifluorormethanesulfonic acid (1493-13-6) + 2-Chlorobenzenediazonium o-benzenedisulfonimide → 2-chlorophenyl triflate (66107-36-6)

Guidance literature:

at 120 ℃; for 1.5h;

DOI:10.1055/s-1999-3696

upstream raw materials:

trifluorormethanesulfonic acid

2-chlorobenzenediazonium tetrafluoroborate

trifluoromethylsulfonic anhydride

2-monochlorophenol

Downstream raw materials:

(S)-2-(2-chlorophenyl)-2,3-dihydrofuran

(R)-2-(2-chlorophenyl)-2,3-dihydrofuran

(R)-2-(2-chlorophenyl)-2,5-dihydrofuran

(S)-2-(2-chlorophenyl)-2,5-dihydrofuran

Refernces

• 1、 Reeves, Emily K.,Humke, Jenna N.,Neufeldt, Sharon R.. "N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki-Miyaura Cross Coupling". . p. 11799 - 11812. Retrieved 2019/10/11.
• 2、 Hall, Catherine,Henderson, Jaclyn L.,Ernouf, Guillaume,Greaney, Michael F.. "Tandem thia-Fries rearrangement-cyclisation of 2-(trimethylsilyl)phenyl trifluoromethanesulfonate benzyne precursors". supporting information. p. 7602 - 7604. Retrieved 2013/09/02.