4-Amino-2-iodophenol

Base Information

• Chemical Name: 4-Amino-2-iodophenol
• CAS No.: 89640-51-7
• Molecular Formula: C6H6INO
• Molecular Weight: 235.024
• Hs Code.: 2922299090
• European Community (EC) Number: 694-409-7
• DSSTox Substance ID: DTXSID10549051
• Nikkaji Number: J36.223I
• Wikidata: Q82427925
• Mol file: 89640-51-7.mol

Synonyms:4-amino-2-iodophenol;89640-51-7;4-HYDROXY-3-IODOANILINE;3-Iodo-4-hydroxyaniline;4-amino-2-iodo-phenol;4-hydroxy-3-iodo-aniline;SCHEMBL1628474;DTXSID10549051;WLZ3457;4-Amino-2-iodophenol (4A2IP);GUGSDWSSHLBVST-UHFFFAOYSA-N;BDBM217398;MFCD06656564;AKOS015150482;BS-23888;4-Amino-2-iodophenol, >=95.0% (HPLC);AM20041350;D84192;EN300-1272192

Chemical Property of 4-Amino-2-iodophenol

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 110-120°C ((subl.)) (lit.)
• Refractive Index: 1.74
• Boiling Point: 286.982 °C at 760 mmHg
• Flash Point: 127.362 °C
• PSA: 46.25000
• Density: 2.094 g/cm³
• LogP: 2.16020
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 234.94941
• Heavy Atom Count: 9
• Complexity: 99.1

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Amino-2-iodophenol ≥95.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1N)I)O

Technology Process of 4-Amino-2-iodophenol

There total 6 articles about 4-Amino-2-iodophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

2,6-diiodo-4-nitrophenol (305-85-1) → 4-amino-2-iodophenol (89640-51-7)

Guidance literature:

With sodium hydroxide; sodium dithionite; at 75 ℃;

DOI:10.1021/jm00111a051

Reference yield:

2-iodo-4-nitrophenol (89487-91-2) → 4-amino-2-iodophenol (89640-51-7)

Guidance literature:

With tin(ll) chloride; In ethanol; at 70 ℃; for 15h; Inert atmosphere;

DOI:10.1248/cpb.c16-00237

Reference yield:

m-iodonitrobenzene (645-00-1) → 4-amino-2-iodophenol (89640-51-7)

Guidance literature:

With sulfuric acid; at 80 ℃; (electrochemical reduction);

upstream raw materials:

m-iodonitrobenzene

2-Iodophenol

2,6-diiodo-4-nitrophenol

2-hydroxy-5-nitroaniline

Downstream raw materials:

C₂₁H₂₁IN₄O₆

2-iodocyclohexa-2,5-diene-1,4-dione

4-acetamido-2-iodophenyl acetate

2-iodo-4-(6-methyl-pyrido[3,4-d]pyrimidin-4-ylamino)-phenol hydrochloride

Refernces

• 1、 Okitsu, Takashi,Ogasahara, Mizuki,Wada, Akimori. "Convergent synthesis of dronedarone, an antiarrhythmic agent". . p. 1149 - 1153. Retrieved 2016/08/11.
• 2、 -. "Hair conditioning compositions and their use in hair colouring compositions". . . Retrieved 2008/06/13.