3-FLUORO-2-(N-MORPHOLINO)-BENZALDEHYDE

Base Information

• Chemical Name: 3-FLUORO-2-(N-MORPHOLINO)-BENZALDEHYDE
• CAS No.: 736991-35-8
• Molecular Formula: C11H12FNO2
• Molecular Weight: 209.22
• Hs Code.: 2934999090
• Mol file: 736991-35-8.mol

Synonyms:3-Fluoro-2-(morpholin-4-yl)benzaldehyde;

Chemical Property of 3-FLUORO-2-(N-MORPHOLINO)-BENZALDEHYDE

Chemical Property:

• Vapor Pressure: 0.000124mmHg at 25°C
• Refractive Index: 1.563
• Boiling Point: 335 ºC at 760 mmHg
• PKA: 3.69±0.40(Predicted)
• Flash Point: 156.4 ºC
• PSA: 29.54000
• Density: 1.24 g/cm³
• LogP: 1.53980

Purity/Quality:

98%min ^*data from raw suppliers

3-Fluoro-2-(N-morpholino)-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-2-(N-MORPHOLINO)-BENZALDEHYDE

There total 1 articles about 3-FLUORO-2-(N-MORPHOLINO)-BENZALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

morpholine (110-91-8,99108-56-2) + 2,3-difluorobenzaldehyde (2646-91-5) → 3-fluoro-2-(morpholin-4-yl)benzaldehyde (736991-35-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 20h;

DOI:10.3987/COM-07-11260

Reference yield: 12.0%

3-fluoro-2-(morpholin-4-yl)benzaldehyde (736991-35-8) + 3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid (1356453-55-8) → 3-[(R)-2-cyclohexyl-4-(3-fluoro-2-morpholin-4-ylbenzyl)-6-oxopiperazin-1-yl]-5-phenylthiophene-2-carboxylic acid (1356456-03-5)

Guidance literature:

3-fluoro-2-(morpholin-4-yl)benzaldehyde; 3-((R)-2-cyclohexyl-6-oxopiperazin-1-yl)-5-phenylthiophene-2-carboxylic acid; With acetic acid; In methanol; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In methanol; at 75 ℃; for 3h;

Reference yield:

3-fluoro-2-(morpholin-4-yl)benzaldehyde (736991-35-8) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-[[3-fluoro-2-(morpholin-4-yl)phenyl]methyl]piperazine-1-carboxylate (1446818-61-6)

Guidance literature:

3-fluoro-2-(morpholin-4-yl)benzaldehyde; 1-t-Butoxycarbonylpiperazine; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃;

upstream raw materials:

morpholine

2,3-difluorobenzaldehyde

Downstream raw materials:

3-[(R)-2-cyclohexyl-4-(3-fluoro-2-morpholin-4-ylbenzyl)-6-oxopiperazin-1-yl]-5-phenylthiophene-2-carboxylic acid

tert-butyl 4-[[3-fluoro-2-(morpholin-4-yl)phenyl]methyl]piperazine-1-carboxylate

4-[2-fluoro-6-(piperazin-1-ylmethyl)phenyl]morpholine

1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[3-fluoro-2-(morpholin-4-yl)phenyl]methyl]piperazine-1-carboxylate

Refernces

• 1、 -. "CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME". Paragraph 00268. . Retrieved 2013/10/08.