2-nitro-3,4,5-trichloroanisole

Base Information

• Chemical Name: 2-nitro-3,4,5-trichloroanisole
• CAS No.: 151143-59-8
• Molecular Formula: C₇H₄Cl₃NO₃
• Molecular Weight: 256.473
• Mol file: 151143-59-8.mol

Synonyms:2-nitro-3,4,5-trichloroanisole

Chemical Property of 2-nitro-3,4,5-trichloroanisole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-nitro-3,4,5-trichloroanisole

There total 3 articles about 2-nitro-3,4,5-trichloroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,4,5-trichloroanisole (54135-82-9) → 2-nitro-3,4,5-trichloroanisole (151143-59-8)

Guidance literature:

With sulfuric acid; nitric acid; In acetic anhydride; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)61354-0

Reference yield:

3,5-dichloroanisole (33719-74-3) → 2-nitro-3,4,5-trichloroanisole (151143-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / isocyanuric trichloride / dimethylformamide / 1 h / Ambient temperature

2: 87 percent / fum. HNO₃, conc. H₂SO₄ / acetic anhydride / 0.5 h / 0 °C

With 1,3,5-trichloro-2,4,6-triazine; sulfuric acid; nitric acid; In acetic anhydride; N,N-dimethyl-formamide;

DOI:10.1246/bcsj.67.1449

Reference yield:

3,5-dichlorophenol (591-35-5) → 2-nitro-3,4,5-trichloroanisole (151143-59-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / acetone / 3 h / Ambient temperature

2: 87 percent / isocyanuric trichloride / dimethylformamide / 1 h / Ambient temperature

3: 87 percent / fum. HNO₃, conc. H₂SO₄ / acetic anhydride / 0.5 h / 0 °C

With 1,3,5-trichloro-2,4,6-triazine; sulfuric acid; nitric acid; potassium carbonate; In acetic anhydride; N,N-dimethyl-formamide; acetone;

DOI:10.1246/bcsj.67.1449

upstream raw materials:

3,4,5-trichloroanisole

3,5-dichlorophenol

3,5-dichloroanisole

Downstream raw materials:

2,5-dichloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole

1-(2,3,4-trichloro-6-methoxyphenyl)-2-iodo-1H-pyrrole

2-chloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole

3-chloro-1-(2,3,4-trichloro-6-methoxyphenyl)-1H-pyrrole

Refernces

• 1、 Tatsuta,Itoh. "Synthesis and biological evaluation of neopyrrolomycin analogs". . p. 262 - 265. Retrieved 2007/10/02.
• 2、 Singh, Sudhir K.,Kumar, Subodh. "Synthesis of Oxygenated Derivatives of 2,3,7,8-Tetrachlorodibenzo-p-dioxin". . p. 1511 - 1516. Retrieved 2007/10/02.