L-LEUCINE-2-D1

Base Information

• Chemical Name: L-LEUCINE-2-D1
• CAS No.: 89836-93-1
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 132.167
• Mol file: 89836-93-1.mol

Synonyms:L-[2-2H]Leucine

Chemical Property of L-LEUCINE-2-D1

Chemical Property:

• Melting Point: >300 °C(lit.)
• PSA: 63.32000
• LogP: 1.14470

Purity/Quality:

99% ^*data from raw suppliers

L-Leucine-2-d1 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Leucine-2-d1 (CAS# 89836-93-1) is a useful isotopically labeled research compound.

Technology Process of L-LEUCINE-2-D1

There total 8 articles about L-LEUCINE-2-D1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl (4S)-2-(tert-butyl)-4-isobutyl-5-oxooxazolidine-3-carboxylate-4-d → (S)-α-deuterated leucine (89836-93-1)

Guidance literature:

With hydrogenchloride; In water; at 80 ℃; for 0.5h;

DOI:10.1021/acs.orglett.0c00154

Reference yield: 89.0%

(S)-Z-2-[2H1]-Leu (57224-92-7) → (S)-α-deuterated leucine (89836-93-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 5171.48 - 6205.78 Torr;

DOI:10.1002/(SICI)1099-1344(200004)43:5<449::AID-JLCR331>3.0.CO;2-0

Reference yield: 64.0%

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → (S)-α-deuterated leucine (89836-93-1)

Guidance literature:

In water-d2; at 30 ℃; for 24h; potassium-phophate buffer, pyridoxal-5'-phosphate, lyophilized E_. coli cells containing tryptophanase, anaerobic incubation;

DOI:10.1016/S0040-4039(00)97240-X

upstream raw materials:

L-leucine

sodium 4-methyl-2-oxovalerate

(S)-Z-2-[2H₁]-Leu

(R,S)-2-[2H₁]-Leu

Refernces

• 1、 Dong, Yue,Huang, He,Ji, Peng,Wang, Wei,Wei, Yongyi,Zhang, Yueteng. "Synthesis of Enantioenriched α-Deuterated α-Amino Acids Enabled by an Organophotocatalytic Radical Approach". supporting information. . Retrieved 2020/03/03.
• 2、 Taglang, Céline,Martínez-Prieto, Luis Miguel,Del Rosal, Iker,Maron, Laurent,Poteau, Romuald,Philippot, Karine,Chaudret, Bruno,Perato, Serge,Sam Lone, Ana?s,Puente, Céline,Dugave, Christophe,Rousseau, Bernard,Pieters, Grégory. "Enantiospecific C-H Activation Using Ruthenium Nanocatalysts". supporting information. p. 10474 - 10477. Retrieved 2015/09/02.