(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide

Base Information

• Chemical Name: (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide
• CAS No.: 1431567-21-3
• Molecular Formula: C₂₉H₂₄Cl₂F₂N₂O₇
• Molecular Weight: 621.422
• Mol file: 1431567-21-3.mol

Synonyms:(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide

Chemical Property of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide

There total 2 articles about (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-hydroxyethyl)pyridine 1-oxide + (2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl))acetyl chloride (1431567-20-2) → (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide (1431567-21-3)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃;

Reference yield:

2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetic acid (52208-61-4) → (S)-3,5-dichloro-4-(2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetoxy)ethyl)pyrid ine 1-oxide (1431567-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (dichloromethoxy)ethane / chloroform / 3 h / Reflux

2: dmap / dichloromethane / 20 °C

With dmap; (dichloromethoxy)ethane; In dichloromethane; chloroform;

upstream raw materials:

(2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl))acetyl chloride

2-(1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)acetic acid

Refernces

• 1、 -. "DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS". Page/Page column 204; 205. . Retrieved 2013/05/09.