P-TOLYL ISOCYANATE

Base Information

• Chemical Name: P-TOLYL ISOCYANATE
• CAS No.: 374675-64-6
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.15
• Mol file: 374675-64-6.mol

Synonyms:p-Toluene isocyanate;p-Methylphenyl isocyanate;4-Methylphenyl isocyanate;p-Isocyanatotoluene;4-Isocyanatotoluene;Benzene,1-isocyanato-4-methyl;4-Tolyl isocyanate;

Chemical Property of P-TOLYL ISOCYANATE

Chemical Property:

• Refractive Index: n20/D 1.531(lit.)
• Boiling Point: 70-72 °C10 mm Hg(lit.)
• Flash Point: 152 °F
• PSA: 29.43000
• Density: 1.056 g/mL at 25 °C(lit.)
• LogP: 1.96230
• Storage Temp.: 0-6°C

Purity/Quality:

99% ^*data from raw suppliers

4-Tolylisocyanate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-42
• Safety Statements: 23-26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of P-TOLYL ISOCYANATE

There total 89 articles about P-TOLYL ISOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis(trichloromethyl) carbonate (32315-10-9) + p-toluidine (106-49-0,12221-03-3) → p-Tolylisocyanate (622-58-2,374675-64-6)

Guidance literature:

In chloroform; at 20 ℃; for 2h; Cooling with ice;

DOI:10.1038/ja.2016.42

Reference yield: 90.0%

methyl p-tolylcarbamate (5602-96-0) → p-Tolylisocyanate (622-58-2,374675-64-6)

Guidance literature:

With phosphorus pentachloride; at 120 - 140 ℃; for 3h;

Reference yield: 80.0%

para-methylbenzamide (619-55-6) → p-Tolylisocyanate (622-58-2,374675-64-6)

Guidance literature:

With [N-(p-tolylsulfonyl)imino]phenyliodinane; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo300007c

upstream raw materials:

phosgene

p-toluidine

p-tolyl-carbamic acid benzyl ester

ethanolamine

Downstream raw materials:

p-tolyl-carbamic acid-((S)-2-methyl-butyl ester)

N-p-tolylcarbamoyl-L-methionine

p-tolyl-carbamic acid-(2-fluoro-ethyl ester)

3β-p-tolylcarbamoyloxy-stigmasta-5,22t-diene

Refernces

• 1、 -. "Insecticidal sterilization composition and application thereof". Paragraph 0011-0012; 0041; 0043; 0049; 0051; 0057; 0059. . Retrieved 2021/11/03.
• 2、 Akwii, Racheal,Alvina, Karina,Ashraf-Uz-Zaman, Md,Farshbaf, Mohammad Jodeiri,German, Nadezhda A.,Kallem, Raja Reddy,Mikelis, Constantinos M.,Putnam, William,Sajib, Md Sanaullah,Shahi, Sadisna,Trippier, Paul C.,Wang, Wei,Zhang, Ruiwen. "Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer". . . Retrieved 2020/10/12.