3-BROMOTHIOPHENE-4-BORONIC ACID

Base Information

• Chemical Name: 3-BROMOTHIOPHENE-4-BORONIC ACID
• CAS No.: 101084-76-8
• Molecular Formula: C4H4BBrO2S
• Molecular Weight: 206.85
• Hs Code.: 2934999090
• Mol file: 101084-76-8.mol

Synonyms:3-Thiopheneboronicacid, 4-bromo- (6CI);Boronic acid, (4-bromo-3-thienyl)- (9CI);(4-Bromo-3-thienyl)boronic acid;(4-Bromothiophen-3-yl)boronic acid;

Chemical Property of 3-BROMOTHIOPHENE-4-BORONIC ACID

Chemical Property:

• Appearance/Colour: off-white solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 193-195 °C
• Refractive Index: 1.63
• Boiling Point: 353.208 °C at 760 mmHg
• PKA: 7.98±0.58(Predicted)
• Flash Point: 167.415 °C
• PSA: 68.70000
• Density: 1.879 g/cm³
• LogP: 0.19040
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-Bromothiophene-3-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMOTHIOPHENE-4-BORONIC ACID

There total 2 articles about 3-BROMOTHIOPHENE-4-BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dibromothiophene (3141-26-2) → 3-bromothiophene-4-boronic acid (101084-76-8)

Guidance literature:

With n-butyllithium; diethyl ether; at -60 ℃; anschliessend Behandeln mit Tributylborat in Aether und Behandeln des Reaktionsgemisches mit wss. Salzsaeure;

Reference yield:

4-bromo-[3]thienyl lithium (19162-83-5) + diethyl ether (60-29-7,927820-24-4) + boric acid tributyl ester (688-74-4) → 3-bromothiophene-4-boronic acid (101084-76-8)

Guidance literature:

anschliessend Behandeln mit wss. Salzsaeure;

Reference yield: 69.0%

2,2',5-tribromo-4-iodobiphenyl (959589-04-9) + 3-bromothiophene-4-boronic acid (101084-76-8) → C16H8Br4S (1421029-29-9)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere;

DOI:10.1002/asia.201200631

upstream raw materials:

4-bromo-[3]thienyl lithium

diethyl ether

boric acid tributyl ester

3,4-dibromothiophene

Downstream raw materials:

C₁₆H₈Br₄S