3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester
• CAS No.: 540523-98-6
• Molecular Formula: C₁₁H₁₀ClNO₅
• Molecular Weight: 271.657
• Mol file: 540523-98-6.mol

Synonyms:3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester

Chemical Property of 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester

There total 1 articles about 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2-nitrotoluene (89-59-8) + oxalic acid diethyl ester (95-92-1) → 3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester (540523-98-6)

Guidance literature:

With potassium ethoxide; In ethanol; Heating;

DOI:10.1021/jm00400a009

Reference yield:

3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester (540523-98-6) → 6-chloro-1H-indole-2-carboxylic acid (16732-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl

2: FeSO₄/NH₃

With hydrogenchloride; ammonia; iron(II) sulfate;

DOI:10.1021/jm00400a009

Reference yield:

3-(4-chloro-2-nitro-phenyl)-2-oxo-propionic acid ethyl ester (540523-98-6) → 6-chloro-1-(diphenylmethyl)-2-[(E)-2-nitrovinyl]-1H-indole (934285-82-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 16.8 g / AcOH; Fe / ethanol / 4 h / Heating

2: LiAlH₄ / tetrahydrofuran / 3.5 h / 0 °C

3: 4.23 g / MnO₂ / tetrahydrofuran / 16 h / 0 °C

4: 40 percent / NaH; Bu₄NI / dimethylformamide / 42 h / 0 °C

5: 49 percent / NH₄OAc / 1.17 h / 95 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; ammonium acetate; tetra-(n-butyl)ammonium iodide; iron; sodium hydride; acetic acid; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm061131z

upstream raw materials:

4-chloro-2-nitrotoluene

oxalic acid diethyl ester

Downstream raw materials:

(4-chloro-2-nitro-phenyl)-pyruvic acid

ethyl 6-chloro-1H-indole-2-carboxylate

6-chloro-1-(diphenylmethyl)-1H-indole-2-carbaldehyde

6-chloro-1-(diphenylmethyl)-2-[(E)-2-nitrovinyl]-1H-indole

Refernces

• 1、 Gore, Vivek,Patel, Pranav,Chang, Chih-Tsung,Sivendran, Sashikala,Kang, Namin,Ouedraogo, Yannick P.,Gravel, Sylvie,Powell, William S.,Rokach, Joshua. "5-Oxo-ETE receptor antagonists". . p. 3725 - 3732. Retrieved 2013/06/27.
• 2、 -. "Substituted Heterocycles as Therapeutic agents for treating cancer". Page/Page column 20. . Retrieved 2012/01/13.