4-Pyrimidineacetic acid

Base Information

• Chemical Name: 4-Pyrimidineacetic acid
• CAS No.: 325491-53-0
• Molecular Formula: C₆H₆N₂O₂
• Molecular Weight: 138.126
• Hs Code.: 2933599090
• Mol file: 325491-53-0.mol

Synonyms:2-(Pyrimidin-4-yl)aceticacid;4-Pyrimidinylacetic acid;

Chemical Property of 4-Pyrimidineacetic acid

Chemical Property:

• Vapor Pressure: 0.000188mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 315.1 °C at 760 mmHg
• Flash Point: 144.4 °C
• PSA: 63.08000
• Density: 1.336 g/cm³
• LogP: 0.10370
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

Pyrimidin-4-yl-acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyrimidineacetic acid

There total 2 articles about 4-Pyrimidineacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(pyrimidin-4-yl)acetate (1240606-58-9) → 2-(4-Pyrimidyl)acetic acid (325491-53-0)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

4-Methylpyrimidine (3438-46-8) → 2-(4-Pyrimidyl)acetic acid (325491-53-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -70 °C

1.2: 96 h / -70 - 20 °C

2.1: sodium hydroxide / ethanol / 24 h / 20 °C / Inert atmosphere

With sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;

Reference yield:

2-(4-Pyrimidyl)acetic acid (325491-53-0) → 2-methoxy-2-(4-pyrimidyl)thioacetamide + methyl 2-(pyrimidin-4-yl)acetate (863032-29-5)

Guidance literature:

In hydrogenchloride;

upstream raw materials:

ethyl 2-(pyrimidin-4-yl)acetate

4-Methylpyrimidine

Downstream raw materials:

methyl 2-(pyrimidin-4-yl)acetate

Refernces