2-Bromo-5-methylthiazole

Base Information

• Chemical Name: 2-Bromo-5-methylthiazole
• CAS No.: 41731-23-1
• Molecular Formula: C4H4BrNS
• Molecular Weight: 178.052
• Hs Code.: 2934100090
• Mol file: 41731-23-1.mol

Synonyms:2-Bromo-5-methyl-1,3-thiazole;

Chemical Property of 2-Bromo-5-methylthiazole

Chemical Property:

• Vapor Pressure: 0.598mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 195.073 °C at 760 mmHg
• PKA: 1.32±0.10(Predicted)
• Flash Point: 71.778 °C
• PSA: 41.13000
• Density: 1.702 g/cm³
• LogP: 2.21400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform, Methanol (Slightly)
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Bromo-5-methylthiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41-36
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-5-methylthiazole is a brominated thiazole compound for proteomics research.

Technology Process of 2-Bromo-5-methylthiazole

There total 4 articles about 2-Bromo-5-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

5-methyl-2-thiazol-2-amine (7305-71-7) → 2-bromo-5-methyl-1,3-thiazole (41731-23-1)

Guidance literature:

With N-Bromosuccinimide; sodium nitrite; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1002/chem.201803347

Reference yield:

5-methyl-2-thiazol-2-amine (7305-71-7) + copper(II)bromide (7789-45-9) → 2-bromo-5-methyl-1,3-thiazole (41731-23-1)

Guidance literature:

With tert.-butylnitrite; In acetonitrile;

Reference yield:

→ 2-bromo-5-methyl-1,3-thiazole (41731-23-1)

Guidance literature:

With copper(II) sulfate; sodium bromide;

DOI:10.1021/ja01144a031

upstream raw materials:

5-methylthiazole

5-methyl-2-thiazol-2-amine

copper(II)bromide

Downstream raw materials:

4-nitro-N-5-methyl-thiazol-2-yl-benzenesulfonamide

2-(4-aminobenzenesulfonylamido)-5-methylthiazole

1-(5-methyl-thiazol-2-yl)-piperazine

2-iodo-5-methylthiazole

Refernces

• 1、 Rao, Ying-Li,Amarne, Hazem,Chen, Leanne D.,Brown, Matthew L.,Mosey, Nicholas J.,Wang, Suning. "Photo- and thermal-induced multistructural transformation of 2-phenylazolyl chelate boron compounds". supporting information. p. 3407 - 3410. Retrieved 2013/04/23.
• 2、 Yu, Haibo,Qin, Zhenfang,Dai, Hong,Zhang, Xin,Qin, Xue,Wang, Tingting,Fang, Jianxin. "Synthesis and insecticidal activity of N-substituted (1,3-thiazole)alkyl sulfoximine derivatives". scheme or table. p. 11356 - 11360. Retrieved 2010/04/02.