4-chloro-2-vinylbenzaldehyde

Base Information

• Chemical Name: 4-chloro-2-vinylbenzaldehyde
• CAS No.: 1370529-71-7
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.607
• Mol file: 1370529-71-7.mol

Synonyms:4-chloro-2-vinylbenzaldehyde

Chemical Property of 4-chloro-2-vinylbenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4-chloro-2-vinylbenzaldehyde

There total 3 articles about 4-chloro-2-vinylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-bromo-4-chlorobenzaldehyde (84459-33-6) + potassium vinyltrifluoroborate → 4-chloro-2-vinylbenzaldehyde (1370529-71-7)

Guidance literature:

With caesium carbonate; triphenylphosphine; palladium dichloride; In tetrahydrofuran; water;

DOI:10.1016/j.ejmech.2018.02.024

Reference yield:

trifluoro(vinyl)-borane potassium salt + 2-bromo-4-chlorobenzaldehyde (84459-33-6) → 4-chloro-2-vinylbenzaldehyde (1370529-71-7)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 70 ℃; for 4h; Sealed tube;

DOI:10.1021/acs.orglett.1c03772

Reference yield:

tri-n-butyl(vinyl)tin (7486-35-3) + 2-bromo-4-chlorobenzaldehyde (84459-33-6) → 4-chloro-2-vinylbenzaldehyde (1370529-71-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 12h; Reflux;

DOI:10.1039/c7ob02167d

upstream raw materials:

tri-n-butyl(vinyl)tin

2-bromo-4-chlorobenzaldehyde

Downstream raw materials:

C₁₇H₁₅ClO₃

C₁₅H₁₁ClO

C₁₇H₁₃ClO₃

C₁₅H₁₁ClO₂

Refernces

• 1、 Xu, Pengcheng,Qian, Bo,Hu, Bin,Huang, Hanmin. "Palladium-Catalyzed Tandem Hydrocarbonylative Lactamization and Cycloaddition Reaction for the Construction of Bridged Polycyclic Lactams". supporting information. p. 147 - 151. Retrieved 2022/01/04.
• 2、 Chen, Hui,Jin, Weiwei,Yu, Shouyun. "Enantioselective Remote C(sp3)-H Cyanation via Dual Photoredox and Copper Catalysis". supporting information. p. 5910 - 5914. Retrieved 2020/08/12.