(S) 2-CYANOPIPERIDINE

Base Information

• Chemical Name: (S) 2-CYANOPIPERIDINE
• CAS No.: 42457-10-3
• Molecular Formula: C6H10N2
• Molecular Weight: 110.159
• Hs Code.: 2933399990
• Mol file: 42457-10-3.mol

Synonyms:Pipecolonitrile(6CI,7CI);2-Piperidinecarbonitrile;

Chemical Property of (S) 2-CYANOPIPERIDINE

Chemical Property:

• Vapor Pressure: 0.082mmHg at 25°C
• Refractive Index: 1.475
• Boiling Point: 226.403 °C at 760 mmHg
• PKA: 6.65±0.10(Predicted)
• Flash Point: 90.726 °C
• Density: 0.99 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: Dichloromethane

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Cyanopiperidine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38-41
• Safety Statements: 26-36-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Cyanopiperidine (cas# 42457-10-3) is a compound useful in organic synthesis.

Technology Process of (S) 2-CYANOPIPERIDINE

There total 20 articles about (S) 2-CYANOPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

piperidine (110-89-4) + trimethylsilyl cyanide (7677-24-9) → piperidine-2-carbonitrile (42457-10-3,1217629-89-4,1434126-85-8)

Guidance literature:

With molecular sieve; benzeneseleninic acid; In dichloromethane; at 20 ℃; for 70h;

DOI:10.1016/S0040-4039(00)98440-5

Reference yield: 75.0%

1-hydroxypiperidine-2-carbonitrile (102739-96-8) → piperidine-2-carbonitrile (42457-10-3,1217629-89-4,1434126-85-8)

Guidance literature:

With titanium(III) chloride; In methanol; Ambient temperature;

DOI:10.1016/S0040-4039(00)98771-9

Reference yield: 65.0%

piperidine (110-89-4) + N-chloropiperidine (2156-71-0) + aqueous hydrogen cyanide + tert-butylhypochlorite (507-40-4) → piperidine-2-carbonitrile (42457-10-3,1217629-89-4,1434126-85-8)

Guidance literature:

With hydrogenchloride; sodium methylate; In methanol;

upstream raw materials:

Tripiperidin

hydrogen cyanide

piperidine

trimethylsilyl cyanide

Downstream raw materials:

2-cyanopiperidine-1-carboxylic acid tert-butyl ester

2-cyano-1-(3-phenoxypropyl)piperidine

1-methyl-2-piperidinecarbonitrile

(±)-1-tert-butoxycarbonyl-2-methylpiperidine-2-carboxylic acid

Refernces

• 1、 Orejarena Pacheco, Julio Cesar,Lahm, Günther,Opatz, Till. "Synthesis of alkaloids by stevens rearrangement of nitrile-stabilized ammonium ylides: (±)-laudanosine, (±)-laudanidine, (±)-armepavine, (±)-7-methoxycryptopleurine, and (±)-xylopinine". . p. 4985 - 4992. Retrieved 2013/06/27.
• 2、 Bahde, Robert J.,Rychnovsky, Scott D.. "Cyclization via carbolithiation of α-amino alkyllithium reagents". supporting information; experimental part. p. 4017 - 4020. Retrieved 2009/06/18.