2-HYDROXY-3-PYRAZINECARBOXYLIC ACID

Base Information

• Chemical Name: 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID
• CAS No.: 20737-42-2
• Molecular Formula: C5H4N2O3
• Molecular Weight: 140.098
• Hs Code.: 2933998090
• Mol file: 20737-42-2.mol

Synonyms:Pyrazinecarboxylicacid, 3,4-dihydro-3-oxo- (9CI);Pyrazinecarboxylic acid, 3-hydroxy- (8CI);Pyrazinoic acid, 3-hydroxy- (6CI);3-Hydroxypyrazinecarboxylic acid;

Chemical Property of 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.17E-15mmHg at 25°C
• Melting Point: 218-220 °C
• Refractive Index: 1.662
• Boiling Point: 608.49 °C at 760 mmHg
• PKA: 12.72±0.20(Predicted)
• Flash Point: 321.804 °C
• PSA: 83.31000
• Density: 1.613 g/cm³
• LogP: -0.11960
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Oxo-3,4-dihydropyrazine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID

There total 10 articles about 2-HYDROXY-3-PYRAZINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 3-oxo-3,4-dihydropyrazine-2-carboxylic acid (20737-42-2)

Guidance literature:

Reference yield: 66.0%

3-aminopyrazinoic acid (5424-01-1) → 3-oxo-3,4-dihydropyrazine-2-carboxylic acid (20737-42-2)

Guidance literature:

3-aminopyrazinoic acid; With sulfuric acid; sodium nitrite; at 0 ℃; for 1h;

With water; Cooling;

Reference yield: 66.0%

C5H7N3O2 → 3-oxo-3,4-dihydropyrazine-2-carboxylic acid (20737-42-2)

Guidance literature:

C₅H₇N₃O₂; With sulfuric acid; sodium nitrite; at 0 ℃; for 1h;

With water;

upstream raw materials:

3-oxo-3,4-dihydropyrazine-2-carboxamide

3-aminopyrazinoic acid

Lumazine

Methyl 3-amino-2-pyrazinecarboxylate

Downstream raw materials:

methyl 3-oxo-3,4-dihydropyrazine-2-carboxylate

4-(3,4-difluorobenzyl)-3-oxo-3,4-dihydropyrazine-2-carboxyIic acid

methyl 4-(3,4-difluorobenzyl)-3-oxo-3,4-dihydiropyrazine-2-carboxylate

3-chloropyrazine-2-carboxylic acid

Refernces

• 1、 Dehghanpour, Saeed,Jahani, Khadijeh,Mahmoudi, Ali,Babakhodaverdi, Mogtaba,Tabatabaei, Robabehsadat,Notash, Behrouz. "Hydrothermal synthesis of 3D Copper(II)-Organic Frameworks: In situ Formation of 3-Hydroxopyrazine-2-carboxylate from 3-Aminopyrazine-2-carboxylic acid". . p. 2312 - 2316. Retrieved 2013.
• 2、 -. "MORPHINAN DERIVATIVE". Paragraph 0180; 0181; 0182. . Retrieved 2018/03/02.
• 3、 -. "ALPHA 7 NICOTINIC ACETYLCHOLINE ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF". Page/Page column 44; 45. . Retrieved 2013/12/03.