4-(4-Methoxyphenyl)pyridine

Base Information

• Chemical Name: 4-(4-Methoxyphenyl)pyridine
• CAS No.: 5938-16-9
• Molecular Formula: C12H11NO
• Molecular Weight: 185.225
• Hs Code.: 2933399090
• Mol file: 5938-16-9.mol

Synonyms:Pyridine,4-(p-methoxyphenyl)- (7CI,8CI);4-(4-Methoxyphenyl)pyridine;4-(p-Methoxyphenyl)pyridine;

Chemical Property of 4-(4-Methoxyphenyl)pyridine

Chemical Property:

• Vapor Pressure: 0.00126mmHg at 25°C
• Melting Point: 38-63 °C
• Refractive Index: 1.56
• Boiling Point: 308.1 °C at 760 mmHg
• PKA: 5.90±0.10(Predicted)
• Flash Point: 113 °C
• PSA: 22.12000
• Density: 1.077 g/cm³
• LogP: 2.75720
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-(4-methoxyphenyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-Methoxyphenyl)pyridine

There total 70 articles about 4-(4-Methoxyphenyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methoxyphenylboronic acid (5720-07-0) + 4-bromopyridine hydrochloride (19524-06-2) → 4-(4-methoxylphenyl)pyridine (5938-16-9)

Guidance literature:

With sodium phosphate; palladium on activated charcoal; In isopropyl alcohol; at 80 ℃; for 3h;

DOI:10.1039/b712207a

Reference yield: 95.0%

4-Chloropyridine (626-61-9) + 4-methoxyphenylboronic acid (5720-07-0) → 4-(4-methoxylphenyl)pyridine (5938-16-9)

Guidance literature:

With potassium phosphate; 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In 1,4-dioxane; at 100 - 110 ℃; Inert atmosphere;

DOI:10.1002/adsc.201100101

Reference yield: 95.0%

para-iodoanisole (696-62-8) + triphenyl(pyridin-4-yl)phosphonium trifluoromethanesulfonate (113964-72-0) → 4-(4-methoxylphenyl)pyridine (5938-16-9)

Guidance literature:

With palladium diacetate; silver perchlorate; potassium carbonate; ruphos; In acetone; at 65 ℃; for 12h; Reagent/catalyst; Solvent; Catalytic behavior; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202006724

upstream raw materials:

pyridine

bis(4-methoxybenzoyl) peroxide

4-methoxy-aniline

1-bromo-4-methoxy-benzene

Downstream raw materials:

4-(4'-methoxyphenyl)-1-(2-phenyl-allyl)pyridinium bromide

C₁₃H₁₄NO⁽¹⁺⁾*I^(1-)

4-(3-bromo-4-methoxyphenyl)pyridine

2-methoxy-5-(4-pyridinyl)phenylboronic acid

Refernces

• 1、 Das, Tapas Kumar,Kundu, Mrinalkanti,Mondal, Biswajit,Ghosh, Prasanjit,Das, Sajal. "Organocatalytic synthesis of (Het)biaryl scaffoldsviaphotoinduced intra/intermolecular C(sp2)-H arylation by 2-pyridone derivatives". . p. 208 - 218. Retrieved 2021/12/29.
• 2、 Cui, Yan-Ying,Na, Jin-He,Guo, Meng-Meng,Huang, Jie-Ying,Chu, Xue-Qiang,Rao, Weidong,Shen, Zhi-Liang. "Cobalt-catalyzed cross-coupling of nitrogen-containing heterocyclic phosphonium salts with arylmagnesium reagents". supporting information. . Retrieved 2022/02/16.