1-BENZOYL-PIPERIDINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 1-BENZOYL-PIPERIDINE-2-CARBOXYLIC ACID
• CAS No.: 78348-46-6
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.267
• Hs Code.: 2933399090
• Mol file: 78348-46-6.mol

Synonyms:Pipecolicacid, 1-benzoyl- (6CI,7CI);1-Benzoyl-2-piperidinecarboxylic acid;1-(Phenylcarbonyl)piperidine-2-carboxylicacid;N-Benzoyl-DL-pipecolinic acid;N-Benzoylpipecolinic acid;1-Benzoylpiperidine-2-carboxylic acid;

Chemical Property of 1-BENZOYL-PIPERIDINE-2-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 1.78E-08mmHg at 25°C
• Refractive Index: 1.582
• Boiling Point: 438.8 °C at 760 mmHg
• Flash Point: 219.2 °C
• PSA: 57.61000
• Density: 1.248 g/cm³
• LogP: 1.70380

Purity/Quality:

98%Min ^*data from raw suppliers

1-Benzoyl-2-piperidinecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZOYL-PIPERIDINE-2-CARBOXYLIC ACID

There total 5 articles about 1-BENZOYL-PIPERIDINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(5,6-dihydropyridin-1(2H)-yl)(phenyl)methanone (71785-91-6) + carbon monoxide (201230-82-2) → N-benzoylpiperidine (776-75-0) + N-benzoyl-2-piperidinecarboxaldehyde (133787-01-6) + N-benzoyl-2-piperidinecarboxylic acid (78348-46-6)

Guidance literature:

With hydrogen; bis-triphenylphosphine-palladium(II) chloride; dicobalt octacarbonyl; In tetrahydrofuran; water; at 110 ℃; for 24h; under 120 Torr; Yields of byproduct given;

DOI:10.1246/bcsj.64.620

Reference yield:

benzoyl chloride (98-88-4) + pipecolic Acid (4043-87-2,83680-83-5) → N-benzoyl-2-piperidinecarboxylic acid (78348-46-6)

Guidance literature:

With sodium hydroxide; In water; at 0 ℃; for 2h;

DOI:10.1021/jo951829c

Reference yield:

ethyl-2-picolinate (2524-52-9,1228273-66-2) → N-benzoyl-2-piperidinecarboxylic acid (78348-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; dioxane / 150 °C / 183877 Torr / Hydrogenation

2: CHCl₃ / Behandeln des Reaktionsprodukts mit wss. NaOH

With 1,4-dioxane; chloroform; nickel;

DOI:10.1002/hlca.19570400310

upstream raw materials:

benzoyl chloride

ethyl pipecolate

(5,6-dihydropyridin-1(2H)-yl)(phenyl)methanone

carbon monoxide

Downstream raw materials:

1-benzoyl-2-(2-phenylethyl)-2-piperidinecarbonitrile

(2S)-6-methoxy-1'-[2-(3-methoxyphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one

(2S)-1'-[2-(3-fluorophenyl)ethyl]-6-methoxy-3,4-dihydro-1Hspiro[naphthalene-2,2'-piperidin]-1-one

(2RS)-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one

Refernces

• 1、 Deur, Christopher J.,Miller, Michael W.,Hegedus, Louis S.. "Photochemical reaction between tertiary allylic amines and chromium carbene complexes: Synthesis of lactams via a zwitterion aza cope rearrangement". . p. 2871 - 2876. Retrieved 2007/10/03.