4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE

Base Information

• Chemical Name: 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE
• CAS No.: 395-68-6
• Molecular Formula: C9H7F3N2O3
• Molecular Weight: 248.161
• Hs Code.: 2924299090
• Mol file: 395-68-6.mol

Synonyms:o-Acetotoluidide,a,a,a-trifluoro-4'-nitro- (6CI,7CI,8CI);N-(4-Nitro-2-trifluoromethylphenyl)acetamide;N1-[4-Nitro-2-(trifluoromethyl)phenyl]acetamide;4'-Nitro-2'-(trifluoromethyl)acetanilide;2-Acetamido-5-nitrobenzotrifluoride;4'-Nitro-2'-(trifluoromethyl)acetanilide 97%;4'-Nitro-2'-(trifluoromethyl)acetanilide97%;

Chemical Property of 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE

Chemical Property:

• Vapor Pressure: 1.01E-05mmHg at 25°C
• Melting Point: 146-150 °C
• Refractive Index: 1.532
• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.7 °C
• PSA: 74.92000
• Density: 1.478 g/cm³
• LogP: 3.16820

Purity/Quality:

99%, ^*data from raw suppliers

4-Nitro-2-(trifluoromethyl)acetanilide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE

There total 3 articles about 4-NITRO-2-(TRIFLUOROMETHYL)ACETANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-(4-Nitrophenyl)acetamide (104-04-1) + Langlois reagent (2926-29-6) → N-(4-nitro-2-(trifluoromethyl)phenyl)acetamide (395-68-6)

Guidance literature:

With tert.-butylhydroperoxide; In dichloromethane; water; at 0 - 15 ℃; for 360h;

DOI:10.1021/jo501221h

Reference yield: 57.0%

→ N-(4-nitro-2-(trifluoromethyl)phenyl)acetamide (395-68-6)

Guidance literature:

With tert.-butylhydroperoxide; In dichloromethane; water; at 0 - 15 ℃; for 120h;

Reference yield:

N-[2-(trifluoromethyl)phenyl]acetamide (344-62-7) → N-(4-nitro-2-(trifluoromethyl)phenyl)acetamide (395-68-6)

Guidance literature:

With sulfuric acid; nitric acid;

DOI:10.1039/jr9510003459

upstream raw materials:

N-[2-(trifluoromethyl)phenyl]acetamide

N-(4-Nitrophenyl)acetamide

Langlois reagent

Downstream raw materials:

1-iodo-4-nitro-2-(trifluoromethyl)benzene

2,2'-bis(trifluoromethyl)benzidine

2,2'-bis-(trifluoromethyl)-4,4'-dinitro-1,1'-biphenyl

2-iodo-5-nitro-benzoic acid

Refernces

• 1、 Wu, Mingxi,Ji, Xinfei,Dai, Wenpeng,Cao, Song. "Copper-free direct C-H trifluoromethylation of acetanilides with sodium trifluoromethanesulfinate". . p. 8984 - 8989. Retrieved 2015/01/09.