1-(4-Chlorophenyl)piperazine Hydrochloride

Base Information

• Chemical Name: 1-(4-Chlorophenyl)piperazine Hydrochloride
• CAS No.: 13078-12-1
• Molecular Formula: C10H14Cl2N2
• Molecular Weight: 233.141
• Hs Code.: 2933599090
• European Community (EC) Number: 678-801-5
• NSC Number: 71659
• DSSTox Substance ID: DTXSID60959646
• Mol file: 13078-12-1.mol

Synonyms:1-(4-Chlorophenyl)piperazine Hydrochloride;13078-12-1;1-(4-chlorophenyl)piperazine;hydrochloride;1-(4-Chlorophenyl)piperazine HCl;1-(4-Chlorophenyl)piperazine, HCl;EINECS 254-165-0;Piperazine, 1-(4-chlorophenyl)-, monohydrochloride;NSC 71659;Timtec-Bb Sbb003262;p-CPP HCl (para-Chlorophenylpiperazine Hydrochloride) 1.0 mg/ml in Methanol (as free base);para-Chlorophenylpiperazine Hydrochloride;NSC71659;1-(4-Chlorophenyl)piperazinehydrochloride;1-(4-chlorophenyl)-piperazine hydrochloride;SCHEMBL708482;DTXSID60959646;ZHGRQBSZTVJDHU-UHFFFAOYSA-N;MFCD00060187;NSC-71659;AKOS003851109;AC-25796;DS-15464;1-(4-chloro-phenyl)piperazine hydrochloride;1-(4-chlorophenyl) piperazine hydrochloride;4-(4-chlorophenyl)-piperazine hydrochloride;N-(4-chlorophenyl)-piperazine hydrochloride;C1117;CS-0444415;FT-0605702;1-(4-chloro-phenyl)-piperazine hydrochloride;F21390;1-(4-Chlorophenyl)piperazine--hydrogen chloride (1/1);p-CPP HCl (para-Chlorophenylpiperazine Hydrochloride;1-(4-Chlorophenyl)piperazine Hydrochloride)

Chemical Property of 1-(4-Chlorophenyl)piperazine Hydrochloride

Chemical Property:

• Appearance/Colour: Gray power
• Vapor Pressure: 0.000113mmHg at 25°C
• Melting Point: 277 °C (dec.)
• Boiling Point: 336.3 °C at 760 mmHg
• Flash Point: 157.2 °C
• PSA: 15.27000
• LogP: 2.94540
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 232.0534038
• Heavy Atom Count: 14
• Complexity: 149

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Chlorophenyl)piperazine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1)C2=CC=C(C=C2)Cl.Cl

Technology Process of 1-(4-Chlorophenyl)piperazine Hydrochloride

There total 2 articles about 1-(4-Chlorophenyl)piperazine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 4-chloro-aniline (106-47-8) → 1-(4-chlorophenyl)piperazine hydrochloride (13078-12-1)

Guidance literature:

With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃; for 12h;

DOI:10.1016/j.bmc.2016.09.005

Reference yield:

→ 1-(4-chlorophenyl)piperazine dihydrochloride (13078-12-1,38869-46-4)

Guidance literature:

Reference yield: 100.0%

Ethyl oxalyl chloride (4755-77-5) + 1-(4-chlorophenyl)piperazine hydrochloride (13078-12-1) → C14H17ClN2O3 (948022-49-9)

Guidance literature:

With potassium carbonate; In toluene; at 0 ℃; for 0.5h;

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

4-chloro-aniline

Downstream raw materials:

6-<2-<4-(4-chlorophenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine

6-{3-[4-(4-Chloro-phenyl)-piperazin-1-yl]-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine

2-<2-<4-(4-chlorophenyl)-1-piperazinyl>ethyl>-1,2,3,4,6,7,8,9-octahydrobenzo<1,6>naphthyridine

6-<2-<4-(4-chlorophenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine difumarate

Refernces

• 1、 Paudel, Suresh,Sun, Ningning,Khadka, Daulat Bikram,Yoon, Goon,Kim, Kyeong-Man,Cheon, Seung Hoon. "Design, synthesis and docking study of 4-arylpiperazine carboxamides as monoamine neurotransmitters reuptake inhibitors". . p. 4127 - 4135. Retrieved 2018/07/21.
• 2、 Zhou, Benhua,Hong, Kwon Ho,Ji, Min,Cai, Jin. "Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands". . p. 1597 - 1609. Retrieved 2018/07/31.