METHOTREXATE HYDRATE

Base Information

• Chemical Name: METHOTREXATE HYDRATE
• CAS No.: 133073-73-1
• Molecular Formula: C20H22 N8 O5 . x H2 O
• Molecular Weight: 472.45
• Hs Code.: 29339980
• Mol file: 133073-73-1.mol

Synonyms:(+)AMETHOPTERINE HYDRATE;(+)-AMETHOPTERIN HYDRATE;4-AMINO-10-METHYLFOLIC ACID HYDRATE;METHYLAMINOPTERIN HYDRATE;METHOTREXATE HYDRATE;L-4-AMINO-N10-METHYLPTEROYL-GLUTAMIC ACID HYDRATE;L-(+)-AMETHOPTERIN HYDRATE;L-AMETHOPTERIN HYDRATE

Chemical Property of METHOTREXATE HYDRATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 195 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 210.54000
• Density: 1.536g/cm³
• LogP: 1.82170
• Storage Temp.: −20°C
• Solubility.: H2O: insoluble

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methotrexate Trihydrate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 61-25-36/38-46
• Safety Statements: 53-26-36/37-45-36

MSDS Files:

SDS file from LookChem

Useful:

• Description: Methotrexate (MTX) is similar in structure to folic acid and aminopterin . It acts by inhibiting the metabolism of folic acid and blocking key enzymes in the synthesis of purines and pyrimidines required for cell proliferation. MTX is known to induce adenosine release, which mediates many of its anti-inflammatory effects, including the reduction of proinflammatory cytokines. Formulations containing MTX have been used as immunosuppressants, in the treatment of cancer, autoimmune disease, ectopic pregnancy, and for the induction of medical abortions. MTX formulations have been considered the gold standard of disease-modifying antirheumatic drug (DMARD) therapy to treat both the immune-inflammatory and joint destructive processes of rheumatoid arthritis.
• Uses: Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis. Methotrexate hydrate has been used: as a dihydrofolate (DHFR)?inhibitor in sphere forming assay cultureas a component of dulbecco′ modified Eagle′s medium (DMEM) for selection of transfected cells in viability and co-culture assays