L-Homotyrosine hydrobromide

Base Information

• Chemical Name: L-Homotyrosine hydrobromide
• CAS No.: 141899-12-9
• Molecular Formula: C10H14BrNO3
• Molecular Weight: 276.13
• Hs Code.: 2922509090
• Mol file: 141899-12-9.mol

Synonyms:Benzenebutanoicacid, a-amino-4-hydroxy-, hydrobromide,(S)-;Benzenebutanoic acid, a-amino-4-hydroxy-, hydrobromide, (aS)- (9CI);

Chemical Property of L-Homotyrosine hydrobromide

Chemical Property:

• Melting Point: 220-225°C
• PSA: 83.55000
• LogP: 2.39510
• Storage Temp.: Store at 0-5°C
• Solubility.: DMSO, Methanol

Purity/Quality:

99% ^*data from raw suppliers

Homo-L-tyrosine hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Homo-L-tyrosine hydrobromide is used in the preparation of azoles as oral antidiabetic agents.

Technology Process of L-Homotyrosine hydrobromide

There total 1 articles about L-Homotyrosine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-(methylcarbamoyl)homotyrosine methyl ester (110936-12-4) → L-homotyrosine hydrobromide (141899-12-9,185617-14-5)

Guidance literature:

With hydrogen bromide; acetic acid; at 60 ℃; for 76h;

DOI:10.1021/jm00093a018

Reference yield: 89.0%

methanol (67-56-1) + L-homotyrosine hydrobromide (141899-12-9,185617-14-5) → homotyrosine methyl ester hydrochloride

Guidance literature:

With acetyl chloride; Reflux;

Reference yield: 77.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + L-homotyrosine hydrobromide (141899-12-9,185617-14-5) → Fmoc-hTyrOH (198560-10-0)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 0 - 25 ℃; for 2h;

DOI:10.1016/S0968-0896(00)00097-3

upstream raw materials:

N-(methylcarbamoyl)homotyrosine methyl ester

Downstream raw materials:

O-(2,6-dichlorobenzyl)-L-homotyrosine

Fmoc-hTyrOH

(S)-2-Amino-4-(4-benzyloxy-phenyl)-butyric acid

(S)-2-{[(2S,4R)-4-Benzyloxy-1-((2S,3R)-3-benzyloxy-2-tert-butoxycarbonylamino-butyryl)-pyrrolidine-2-carbonyl]-amino}-4-(4-benzyloxy-phenyl)-butyric acid methyl ester

Refernces