C₄₄H₅₂N₆O₇

Base Information

• Chemical Name: C₄₄H₅₂N₆O₇
• CAS No.: 1310735-58-0
• Molecular Formula: C₄₄H₅₂N₆O₇
• Molecular Weight: 776.933
• Mol file: 1310735-58-0.mol

Synonyms:C₄₄H₅₂N₆O₇

Chemical Property of C₄₄H₅₂N₆O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₄H₅₂N₆O₇

There total 4 articles about C₄₄H₅₂N₆O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H34N4O4*ClH (1310735-25-1) + (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (66863-43-2) → C44H52N6O7 (1310735-58-0)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 18h; under 750.075 Torr; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.03.029

Reference yield:

Boc-Leu-Phe-Trp-OCH3 (1201848-45-4) → C44H52N6O7 (1310735-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate / 0 °C / 750.08 Torr / Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 18 h / 0 - 20 °C / 750.08 Torr / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;

DOI:10.1016/j.ejmech.2011.03.029

Reference yield:

L-Tryptophan (73-22-3,27732-43-0,80206-30-0,27813-82-7) → C44H52N6O7 (1310735-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sulfuric acid / water / 2 h / 20 °C / 750.08 Torr / Inert atmosphere

1.2: 750.08 Torr / pH 6 - 7 / Inert atmosphere

2.1: triethylamine / N,N-dimethyl-formamide / 20 °C / 750.08 Torr / Inert atmosphere

3.1: 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 18 h / 0 - 20 °C / 750.08 Torr / Inert atmosphere

With 4-methyl-morpholine; sulfuric acid; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide; 1.1: Pictet-Spengler reaction;

DOI:10.1016/j.ejmech.2011.03.029

upstream raw materials:

Boc-Leu-Phe-Trp-OCH₃

C₂₇H₃₄N₄O₄*ClH

(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid

L-Tryptophan

Downstream raw materials:

N-((3S)-1,2,3,4-tetrahydro-β-carboline-3-carboxyl)-Leu-Phe-Trp

Refernces