3-Fluoro-4-nitroanisole

Base Information

• Chemical Name: 3-Fluoro-4-nitroanisole
• CAS No.: 446-38-8
• Molecular Formula: C7H6FNO3
• Molecular Weight: 171.128
• Hs Code.: 2909309090
• Mol file: 446-38-8.mol

Synonyms:Anisole,3-fluoro-4-nitro- (8CI);2-Fluoro-4-methoxy-1-nitrobenzene;2-Fluoro-4-methoxynitrobenzene;3-Fluoro-1-methoxy-4-nitrobenzene;3-Fluoro-4-nitrophenyl methyl ether;4-Methoxy-2-fluoro-1-nitrobenzene;AC1LBWS6;AC1Q4N6W;Nitrobenzene,-2-fluoro,-4-methoxy;CID565654;

Chemical Property of 3-Fluoro-4-nitroanisole

Chemical Property:

• Vapor Pressure: 0.0159mmHg at 25°C
• Melting Point: 57.3 °C
• Refractive Index: 1.521
• Boiling Point: 264.5 °C at 760 mmHg
• Flash Point: 113.7 °C
• PSA: 55.05000
• Density: 1.321 g/cm³
• LogP: 2.26570
• Storage Temp.: Keep Cold

Purity/Quality:

98% ^*data from raw suppliers

3-Fluoro-4-nitroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-4-nitroanisole

There total 11 articles about 3-Fluoro-4-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-4-nitrophenol (394-41-2) + methyl iodide (74-88-4) → 2-fluoro-4-methoxy-1-nitro-benzene (446-38-8)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 48h; Darkness; Sonication;

DOI:10.1002/chem.200801868

Reference yield: 100.0%

3-fluoro-4-nitrophenol (394-41-2) + diazomethyl-trimethyl-silane (18107-18-1) → 2-fluoro-4-methoxy-1-nitro-benzene (446-38-8)

Guidance literature:

3-fluoro-4-nitrophenol; With N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; at 0 ℃; for 0.5h;

diazomethyl-trimethyl-silane; With methanol; In acetonitrile; at 20 ℃; for 18h;

Reference yield: 89.0%

3-fluoro-4-nitrophenol (394-41-2) + dimethyl sulfate (77-78-1) → 2-fluoro-4-methoxy-1-nitro-benzene (446-38-8)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1039/c8ob01701h

upstream raw materials:

3-fluoro-4-nitrophenol

dimethyl sulfate

para-methoxynitrobenzene

2,4-Difluoronitrobenzene

Downstream raw materials:

(methoxy-5' nitro-2' anilino)-6 dimethyl-5,8 isoquinoleine

6,7-dimethoxy-N-(5-methoxy-2-nitrophenyl)-1,2,3,4-tetrahydroisoquinoline

ethyl α-cyano-5-methoxy-2-nitrobenzene acetate

(R)-5-methoxy-2-nitrobenzilic acid

Refernces

• 1、 Wang, Qing,Huang, Kun,Cai, Songtao,Liu, Chang,Jiao, Xiaojie,He, Song,Zhao, Liancheng,Zeng, Xianshun. "Synthesis of near-infrared fluorescent rhodamines via an SNArH reaction and their biological applications". . p. 7163 - 7169. Retrieved 2018.
• 2、 -. "FUSED RING HETEROARYL COMPOUNDS AS RIPK1 INHIBITORS". Paragraph 0150. . Retrieved 2021/02/12.
• 3、 -. "Benzotriazine compound with PAR4 antagonistic activity and application thereof". Paragraph 0109; 0111-0112. . Retrieved 2020/08/02.