Z-D-TYR(TBU)-OH DCHA

Base Information

• Chemical Name: Z-D-TYR(TBU)-OH DCHA
• CAS No.: 198828-72-7
• Molecular Formula: C33H48N2O5
• Molecular Weight: 552.74
• Mol file: 198828-72-7.mol

Synonyms:Z-D-Tyr(tBu)-OH;Z-O-tert.butyl-D-tyrosine dicyclohexylamine salt;

Chemical Property of Z-D-TYR(TBU)-OH DCHA

Chemical Property:

• PSA: 96.89000
• LogP: 7.80920
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

Z-D-Tyr(tBu)-OH.DCHA 97+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-D-TYR(TBU)-OH DCHA

There total 1 articles about Z-D-TYR(TBU)-OH DCHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-[(benzyloxy)carbonyl]-O-(tert-butyl)-L-tyrosine, compound with dicyclohexylamine (1:1) (16879-90-6,198828-72-7)

Guidance literature:

aus den Komponenten;

Reference yield:

N-α-benzyloxycarbamoyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt (16879-90-6,198828-72-7) → (S)-N-((S)-1-amino-3-(4-tert-butoxyphenyl)-1-oxopropan-2-yl)-2-(3-phenylthioureido)propanamide (1082954-37-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / Cooling with ice; Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Inert atmosphere

3.2: 48 h / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 h / Inert atmosphere

5.1: methanol / Inert atmosphere

With 4-methyl-morpholine; hydrogen; 1,1'-carbonyldiimidazole; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol;

Reference yield:

N-α-benzyloxycarbamoyl-O-t-butyl-L-tyrosine dicyclohexylammonium salt (16879-90-6,198828-72-7) → C24H31N3O5 (1194838-69-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / Cooling with ice; Inert atmosphere

1.2: 0.5 h / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / Inert atmosphere

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / Inert atmosphere

3.2: 48 h / Inert atmosphere

With 4-methyl-morpholine; hydrogen; 1,1'-carbonyldiimidazole; isobutyl chloroformate; palladium 10% on activated carbon; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol;

Downstream raw materials:

N-Cbz-N-methyl-(O-tert-butyl)tyrosine

[(S)-1-{(R)-1-[({[(S)-1-Benzyl-2-oxo-2-(N'-propionyl-hydrazino)-ethyl]-methyl-carbamoyl}-methyl)-carbamoyl]-ethylcarbamoyl}-2-(4-tert-butoxy-phenyl)-ethyl]-methyl-carbamic acid benzyl ester

(S)-2-amino-N-((S)-1-amino-3-(4-t-butoxyphenyl)-1-oxopropan-2-yl)propanamide

(S)-N-((S)-1-amino-3-(4-tert-butoxyphenyl)-1-oxopropan-2-yl)-2-(3-phenylthioureido)propanamide