N-Adamant-1-yl-p-thiocarbamoylbenzamid

Base Information

• Chemical Name: N-Adamant-1-yl-p-thiocarbamoylbenzamid
• CAS No.: 80634-98-6
• Molecular Formula: C₁₈H₂₂N₂OS
• Molecular Weight: 314.451
• Mol file: 80634-98-6.mol

Synonyms:N-Adamant-1-yl-p-thiocarbamoylbenzamid

Chemical Property of N-Adamant-1-yl-p-thiocarbamoylbenzamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Adamant-1-yl-p-thiocarbamoylbenzamid

There total 3 articles about N-Adamant-1-yl-p-thiocarbamoylbenzamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-Adamant-1-yl-p-cyanbenzamid (80626-00-2) → N-Adamant-1-yl-p-thiocarbamoylbenzamid (80634-98-6)

Guidance literature:

With TEA; hydrogen sulfide; In pyridine; for 16h;

Reference yield:

4-cyanobenzoyl chlorIde (6068-72-0) → N-Adamant-1-yl-p-thiocarbamoylbenzamid (80634-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / 1,2-dichloro-benzene / 1 h / 160 °C / Heating

2: 82 percent / TEA, H₂S / pyridine / 16 h

With TEA; hydrogen sulfide; In pyridine; 1,2-dichloro-benzene;

Reference yield:

amantadine hydrochloride (665-66-7,13878-11-0) → N-Adamant-1-yl-p-thiocarbamoylbenzamid (80634-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / 1,2-dichloro-benzene / 1 h / 160 °C / Heating

2: 82 percent / TEA, H₂S / pyridine / 16 h

With TEA; hydrogen sulfide; In pyridine; 1,2-dichloro-benzene;

upstream raw materials:

N-Adamant-1-yl-p-cyanbenzamid

4-cyanobenzoyl chlorIde

amantadine hydrochloride

Downstream raw materials:

4-(Adamantan-1-ylcarbamoyl)-thiobenzimidic acid methyl ester

p-(Adamant-1-ylcarbamoyl)thiobenzimidsaeuremethylesterhydrochlorid

p-(Adamant-1-ylcarbamoyl)benzamidiniumiodid

p-(Adamant-1-ylcarbamoyl)thiobenzimidsaeuremethylesterhydroiodid

Refernces