H-Glu-OMe

Base Information

• Chemical Name: H-Glu-OMe
• CAS No.: 6384-08-3
• Molecular Formula: C6H11NO4
• Molecular Weight: 161.158
• Hs Code.: 2922509090
• Mol file: 6384-08-3.mol

Synonyms:Glutamicacid, methyl ester (6CI);Glutamic acid 1-methyl ester;Glutamic acid a-methyl ester;L-Glutamic acidmethyl ester;L-Glutamic acid a-methyl ester;Methyl L-glutamate;a-Methyl L-glutamate;

Chemical Property of H-Glu-OMe

Chemical Property:

• Vapor Pressure: 0.000217mmHg at 25°C
• Melting Point: 145℃
• Refractive Index: 14 ° (C=2, H2O)
• Boiling Point: 303.296 °C at 760 mmHg
• PKA: 4.22±0.10(Predicted)
• Flash Point: 137.229 °C
• PSA: 89.62000
• Density: 1.242 g/cm³
• LogP: 0.05180
• Storage Temp.: 2-8°C
• Solubility.: Methanol (Slightly), Water (Sparingly)
• Water Solubility.: Soluble in water.

Purity/Quality:

99% ^*data from raw suppliers

L-GlutamicAcid1-MethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: L-Glutamic acid 1-methyl ester nonessential amino acid that is important to the mammalian central nervous system. It is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ?hepatic coma?).

Technology Process of H-Glu-OMe

There total 8 articles about H-Glu-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BrH*C21H21NO7 (1293992-27-4) → L-glutamic acid 1-methyl ester (6384-08-3)

Guidance literature:

In acetonitrile; for 3.8h; pH=7.2; Solvent; Wavelength; Kinetics; Photolysis; HEPES buffer;

DOI:10.1016/j.tet.2011.01.090

Reference yield:

N-(benzyloxycarbonyl)-L-glutamic acid anhydride (4124-76-9) → L-glutamic acid 1-methyl ester (6384-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylamine; diethyl ether

2: H₂ / Pd

With diethyl ether; hydrogen; N-cyclohexyl-cyclohexanamine; palladium;

Reference yield:

methanol (67-56-1) + L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → L-glutamic acid 1-methyl ester (6384-08-3)

Guidance literature:

With thionyl chloride;

DOI:10.1002/chem.201203923

upstream raw materials:

methanol

N-(benzyloxycarbonyl)-L-glutamic acid anhydride

Z-L-GluOMe

methyl (S)-1-benzoyl-2-oxopyrrolidine-5-carboxylate

Downstream raw materials:

L-glutamic acid

Refernces

• 1、 Arthur, Isaac N.,Hennessy, James E.,Padmakshan, Dharshana,Stigers, Dannon J.,Lesturgez, Stéphanie,Fraser, Samuel A.,Liutkus, Mantas,Otting, Gottfried,Oakeshott, John G.,Easton, Christopher J.. "In situ deprotection and incorporation of unnatural amino acids during cell-free protein synthesis". supporting information. p. 6824 - 6830. Retrieved 2013/06/26.
• 2、 Fernandes, Maria José G.,Costa, Susana P.G.,Gonalves, M. Sameiro T.. "Phototriggering of neuroactive amino acids from 5,6-benzocoumarinyl conjugates". experimental part. p. 2422 - 2426. Retrieved 2011/05/06.