4,4'-DICHLOROCHALCONE

Base Information

• Chemical Name: 4,4'-DICHLOROCHALCONE
• CAS No.: 102692-35-3
• Molecular Formula: C₁₅H₁₀F₂O
• Molecular Weight: 244.241
• Hs Code.: 2914790090
• Mol file: 102692-35-3.mol

Synonyms:2-Propen-1-one,1,3-bis(4-fluorophenyl)-, (E)-;(E)-1,3-Bis(4-fluorophenyl)-2-propen-1-one;

Chemical Property of 4,4'-DICHLOROCHALCONE

Chemical Property:

• Melting Point: 117-119 °C(lit.)
• Boiling Point: 356.6 °C at 760 mmHg
• Flash Point: 136.5 °C
• PSA: 17.07000
• Density: 1.232 g/cm³
• LogP: 3.86090

Purity/Quality:

99% ^*data from raw suppliers

4,4''-Difluorochalcone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-DICHLOROCHALCONE

There total 5 articles about 4,4'-DICHLOROCHALCONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-fluorobenzaldehyde (459-57-4) + 1-(4-fluorophenyl)ethanone (403-42-9) → 4,4'-difluorochalcone (102692-35-3,102692-49-9,2805-56-3)

Guidance literature:

With potassium hydroxide; In ethanol; water; at 15 - 20 ℃; for 4h;

DOI:10.1055/s-0039-1690204

Reference yield: 46.0%

ethyl 1-cyano-3-(4-fluorobenzoyl)-4-hydroxy-2,4,6-tris(4-fluorophenyl)cyclohexanecarboxylate → 2-cyano-3-(4-fluorophenyl)-2-propenoic acid (118409-66-8) + 4,4'-difluorochalcone (102692-35-3,102692-49-9,2805-56-3)

Guidance literature:

ethyl 1-cyano-3-(4-fluorobenzoyl)-4-hydroxy-2,4,6-tris(4-fluorophenyl)cyclohexanecarboxylate; With potassium hydroxide; In ethanol; for 15h; Reflux;

With hydrogenchloride; In water;

Reference yield:

1,3-bis(4-fluorophenyl)prop-2-en-1-ol → (E)-4,4'-(prop-1-ene-1,3-diyl)bis(fluorobenzene) (1332506-69-0) + 4,4'-difluorochalcone (102692-35-3,102692-49-9,2805-56-3)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 1h; chemoselective reaction;

DOI:10.1016/j.tet.2017.05.006

upstream raw materials:

4-fluorobenzaldehyde

1-(4-fluorophenyl)ethanone

C₂₅H₂₅F₃O₃Si

Downstream raw materials:

3,5-Bis-(4-fluoro-phenyl)-1-p-tolyl-4,5-dihydro-1H-pyrazole

1-(4-Chloro-phenyl)-3,5-bis-(4-fluoro-phenyl)-4,5-dihydro-1H-pyrazole

1-[3,5-Bis-(4-fluoro-phenyl)-4,5-dihydro-pyrazol-1-yl]-ethanone

dipropyl 2-(1,3-bis(4-fluorophenyl)-3-oxopropyl)malonate

Refernces

• 1、 Wang, Zhi-Min,Shen, Su-Mei,Shen, Xiu-Yin,Xu, Ya-Qin,Jia, Ai-Quan,Zhang, Qian-Feng. "Heteroleptic ruthenium(II) polypyridine complexes with a series of substituted 2,2′-bipyridine ligands". . p. 851 - 861. Retrieved 2016.
• 2、 Gopinatha, Vindya K.,Mantelingu, Kempegowda,Raghavan, Sathees C.,Rangappa, Kanchugarakoppal S.,Swarup, Hassan A.. "Discovery of Novel Approach for Regioselective Synthesis of Thioxotriaza-Spiro Derivatives via Oxalic Acid". . p. 2004 - 2009. Retrieved 2019.
• 3、 Sadashiva, Rajitha,Naral, Damodara,Kudva, Jyothi,Shivalingegowda, Naveen,Lokanath, Neratur Krishnappagowda,Pampa, Kudigana Jayaprakash. "Synthesis, spectral, biological activity, and crystal structure evaluation of novel pyrazoline derivatives having sulfonamide moiety". . p. 1213 - 1227. Retrieved 2017.
• 4、 Zhuang, Hongfeng,Lu, Nan,Ji, Na,Han, Feng,Miao, Chengxia. "Bu4NHSO4-Catalyzed Direct N-Allylation of Pyrazole and its Derivatives with Allylic Alcohols in Water: A Metal-Free, Recyclable and Sustainable System". supporting information. p. 5461 - 5472. Retrieved 2021/09/29.